Calcinosis and scleroderma.
[Calcinosis and scleroderma]. Aten Primaria. 2019 Apr;51(4):259-260 Authors: Pujol Olivares X PMID: 30961884 [PubMed - in process]
ConclusionsMyocardial fibrosis is an important cause of early heart failure in SSc patients and is associated with poor prognosis. Echocardiography and CMR help establish the diagnosis and enable an appropriate therapeutic strategy to be developed in such cases.ResumoIntroduçãoA esclerose sistémica (ES) é uma doença autoimune sistémica que pode envolver múltiplos órgãos. Apresentamos um caso raro de ES associada a manifestação clínica de fibrose miocárdica no decurso precoce da evolução da doença.Caso clín...
AbstractSystemic sclerosis is associated with an increased prevalence/incidence of coronary artery disease. The aim of this study was to investigate epicardial adipose tissue (EAT) thickness which may contribute to cardio-metabolic risk in systemic sclerosis (SSc) patients without overt cardiac disease. EAT thickness was measured by transthoracic conventional Doppler echocardiography and compared in SSc patients (n = 47) and age- and sex-matched healthy controls (n = 36). The relationships between EAT thickness and markers of cardio-metabolic risk in SSc were examined. EAT thickness was signific...
AbstractFibrosis is unregulated tissue repair that may cause impairment of organ function, especially in end-organ damage. Systemic sclerosis (SSc) is the prototype systemic fibrosing disorder. Classical targets for fibrosis in SSc like transforming growth factor Beta (TGF- β), Interleukin-6 (IL-6), and multiple tyrosine kinases, have not yielded therapeutic benefit. There is multitude of evidence from across different tissues like the heart, lung, skin, liver, colon, and, to some extent, the kidney, that interleukin-17 (IL-17) and its downstream pathways are strongly associated with the initiation and propagation of ...
ConclusionCYR ‐61, which is epigenetically regulated by HDAC‐5, is a potent antifibrotic and proangiogenic mediator in SSc. Therapeutic intervention to promote CYR‐61 activity or increase CYR‐61 levels might be of benefit in SSc.
Older men with severe scleroderma have higher oestrogen levels than postmenopausal women with scleroderma, according to research published inArthritis Research& Therapy.Science Daily
CONCLUSIONS: Speckle-tracking echocardiography demonstrates the mechanics of RV early impairment in SSc that develops and progresses independently from the concomitant LV impairment, which, in turn, may be influenced by peripheral microvascular abnormalities in the absence of macrovascular damage. PMID: 31172928 [PubMed - as supplied by publisher]
CONCLUSIONS: The correlations found between capillaroscopy and severity of SSc are promising before the ongoing prospective study definitively assesses whether capillaroscopy staging predicts complications of SSc. Only two capillaroscopic patterns seem useful: one involving many giant capillaries and haemorrhages and the other with severe capillary loss. PMID: 31172926 [PubMed - as supplied by publisher]
Conclusion: Dermoscopy is a valuable tool not only to diagnose collagen vascular disorders but also for prognostication by correlating with systemic involvement.
AbstractObjectiveTo assess the preclinical efficacy and mechanism of action of an anti ‐CX3CL1 monoclonal antibody (mAb) in systemic sclerosis (SSc).MethodsCultured human dermal fibroblasts were used to evaluate the direct effect of anti ‐CX3CL1mAb on fibroblasts. In addition, bleomycin and growth factor‐induced SSc models were used to investigate the effect of anti‐CX3CL1mAb on leukocyte infiltration, collagen deposition, and vascular damage in the skin.ResultsAnti ‐CX3CL1mAb treatment significantly inhibited Smad3 phosphorylation (p
Condition: Sclerosis, Systemic Intervention: Drug: GLPG1690 Sponsor: Galapagos NV Not yet recruiting