Sedation Optimization: A Core Priority of Modern Quality Improvement in Critical Care*

No abstract available
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Editorials Source Type: research

Related Links:

Publication date: Available online 25 May 2019Source: Antiviral ResearchAuthor(s): B. Praena, R. Bello-Morales, F. de Castro, J.A. López-GuerreroAbstractHerpes simplex virus type 1 (HSV-1) is a ubiquitous infectious agent that can establish latency in neurons, and in some cases, viral retrograde transport results in infection of the central nervous system (CNS). Several antivirals have been identified with the ability to inhibit HSV-1 replication in human cells to a greater or lesser degree, most of which are nucleoside analogues that unfortunately exhibit teratogenic potential, embryotoxicity, carcinogenic or antip...
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: Available online 25 May 2019Source: Antiviral ResearchAuthor(s): R. Farrukee, J. Butler, P.C. Reading, A.C. HurtAbstract:Avian A(H7N9) infections in humans have been reported in China since 2013 and are of public health concern due to their severity and pandemic potential. Oseltamivir and peramivir are neuraminidase inhibitors (NAIs) routinely used for the treatment of A(H7N9) infections, but variants with reduced sensitivity to these drugs can emerge in patients during treatment. Zanamivir and laninamivir are NAIs that are used less frequently. Herein, we performed in vitro serial passaging experiments w...
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: October 2019Source: Current Opinion in Virology, Volume 38Author(s): Bingfeng Liu, Wanying Zhang, Hui ZhangHuman immunodeficiency virus type 1 (HIV-1) reservoir is a pool of latently infected cells harboring replication-competent proviral DNA that limits antiretroviral therapy. Suppression of HIV-1 by combination antiretroviral therapy (cART) delays progression of the disease but does not eliminate the viral reservoir, necessitating lifetime daily administration of antiretroviral drugs. To achieve durable suppression of viremia without daily therapy, various strategies have been developed, including long-...
Source: Current Opinion in Virology - Category: Virology Source Type: research
This report describes a new lethal case of Rickettsia rickettsii infection in a child from Northwestern Colombia, after ten years of the last outbreaks in the same region. Colombian public-health authorities should consider to include this severe rickettsiosis in the compulsory-reporting diseases, with the aim of knowing its burden in the country.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
In this study, we found that the PPL length of Korean SG isolates varied from 11 to 21 prolines and was longer than that of a live vaccine strain, SG 9R (9 prolines). According to growth competition in chickens, the growth of an SG isolate with a PPL length of 17 prolines exceeded that of an SG isolate with a PPL length of 15 prolines. We investigated the pseudogenes of the field isolates, SG 9R and reference strains in GenBank by resequencing and comparative genomics. The pseudogene profiles of the field isolates were notably different from those of the foreign SG strains, and they were subdivided into 7 pseudogene subgro...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
In conclusion, these results indicate that AtlASS autolysin modulates bacterial chain length, and contributes to the full virulence of SS during infection.
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
In this study, in vivo and in vitro survivability and immunogenicity of four coliphages (TM1, TM2, TM3 and TM4) were investigated in naive chickens and chickens pre-immunised with phage TM1. Furthermore, two phages that displayed different survivability and immunogenicity (TM1 and TM3) were compared with respect to their efficacy in treating naive or pre-immunised (TM1) chickens suffering from colibacillosis. The efficacy of the treatments was evaluated based on body weight, relative organ weights, mortality, E. coli counts in the lungs as well as severity and frequency of internal organ lesions. At the end of the experime...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 24 May 2019Source: Veterinary MicrobiologyAuthor(s): Sante Roperto, Valeria Russo, Francesca De Falco, Alessandra Rosati, Cornel Catoi, Franco RopertoAbstractE5 protein, the major oncoprotein of the bovine Deltapapillomavirus genus, has been detected in 17 of the 19 urothelial cancers by molecular and morphological procedures. In 10 urothelial cancers, the oxygen sensitive subunit HIF-1α, which is upregulated by hypoxia, was overexpressed. Mitophagy, the selective autophagic removal of dysfunctional mitochondria, was upregulated in hypoxic neoplastic cells infected by BPVs which was...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 24 May 2019Source: The Veterinary JournalAuthor(s): Miguelita Prinsloo, Philip Hynd, Samantha Franklin, Sarah Weaver, Robin van den BoomAbstractEquine squamous gastric disease (ESGD) is common in horses and many factors, including stress, may play a role in lesion development. Hair cortisol concentration (HCC) provides a measure of medium to long-term stress and therefore, the relationship between HCC and ESGD was examined in this study. Hair samples were collected from 25 horses and gastroscopy was performed to determine the presence and severity of ESGD. Hair cortisol concentrations wer...
Source: The Veterinary Journal - Category: Veterinary Research Source Type: research
Publication date: Available online 25 May 2019Source: Preventive Veterinary MedicineAuthor(s): Ricardo Lopes, Amanda Brinch Kruse, Liza Rosenbaum Nielsen, Telmo Pina Nunes, Lis AlbanAbstractIn modern livestock farming, there is an increasing understanding that antimicrobial (AM) consumption must be kept low – preferably without compromising animal welfare or productivity. This requires an understanding of the relationship between AM use, productivity, biosecurity, vaccination and herd demographics. To obtain this, we undertook an Additive Bayesian Network analysis using data from 2014-15, covering 157 Danish sow herd...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
More News: Pediatrics