Mastectomy Seems to Boost Advanced HER2+ Survival
Surgery was associated with a 44% increased chance of survival, assuming that most patients were also treated with chemo or targeted drug therapies, the study found.
Conclusion: Anti-CV2 autoimmune encephalitis can present as Parkinsonism with bilateral leukoencephalopathy on MRI. PET scanning can be useful to reveal an occult cancer. Treatment of the cancer may improve the paraneoplastic neurological syndrome without the need of immunosuppressive therapy.
AbstractBackgroundA task force was created by the Belgian Society of Medical Oncology (BSMO) to monitor the quality of treatment of breast cancer in Belgium. In collaboration with the Belgian Cancer Registry an analysis of the data was performed in search of reliable quality indicators. Finding actionable differences can lead to better treatment of our patients.MethodsData of 48,872 patients diagnosed with invasive breast cancer between 2010 and 2014 were analysed. To enable risk stratification according to their surrogate subtype, pathology reports of year 2014 were manually checked (9,855 patients). We identified patient...
ConclusionsAccording to this retrospective study, BRCA mutant patients tend to have worse clinical and pathological features comparing age-matched controls.Legal entity responsible for the studySercan Aksoy.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
ConclusionsXIAP-high ” tumors are more prone to metastatic relapse and resistance to chemotherapy, suggesting the therapeutic benefit of targeting XIAP in the neoadjuvant setting.Legal entity responsible for the studyThe authors.FundingDepartment of Defense W81XWH-17-1-0297 (to G.R. Devi) and Duke School of Medicine Bridge Fund (to G.R.Devi).DisclosureAll authors have declared no conflicts of interest.
Conclusions: In case of small, low-risk IBTR, adjuvant re-irradiation using multi-catheter brachytherapy is a feasible, safe, and effective treatment method after repeated lumpectomy, and an alternative to mastectomy. PMID: 31523231 [PubMed]
Abstract PURPOSE: To identify a sub-group at high risk for local-regional recurrence (LRR) from T1-2 breast cancer with negative lymph nodes (N0) after mastectomy by using a meta-analysisMethods and materials:Published studies on the relationship between clinical features and loco-regional recurrence of breast cancer were identified from public databases, including PubMed, EMBASE, and the Cochrane library. High-risk features for LRR in this patient population were defined based on the pooled results of meta-analysis.ResultsFor the meta-analysis, a total of 11,244 breast cancers with pT1-2N0 after mastectomy from 2...
ConclusionsFor intermediate-risk as well as early stage high-risk BC patients, the DEGRO Breast Cancer Expert Panel recommends the use of PMRT following SSME and NSME when a 10-year locoregional recurrence risk is likely to be greater than 10%, as estimated by clinical and biological risk factors. Subvolume-only radiation is discouraged outside of trials. The impact of adequate systemic treatment and the value of radiotherapy on optimal locoregional tumor control, wit h the goal of less than 5% LRR at 10-years follow-up, has to be verified in prospective trials.
Publication date: Available online 20 August 2019Source: Academic RadiologyAuthor(s): Laura Heacock, Alana Lewin, Abimbola Ayoola, Melanie Moccaldi, James S. Babb, Sungheon G. Kim, Linda MoyRationale and ObjectivesPathologic complete response (pCR) in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer after HER2-targeted therapy correlates increased disease-free survival and decreased mastectomy rates. The aim of this study was to explore tumor shrinkage patterns and initial tumor enhancement with pCR in HER2-positive breast cancer.Materials and MethodsThis was an institutional review boar...
CONCLUSIONS: Nine-gauge VAB specimens can be processed within 4 hours. Slides are suitable for all routine pathologic stains. This enables a same-day diagnosis. PMID: 31415692 [PubMed - as supplied by publisher]