Glucose oxidase mimicking half–sandwich nickel(II) complexes of coumarin substituted N–heterocyclic carbenes as novel molecular electrocatalysts for ultrasensitive and selective determination of glucose

Publication date: Available online 29 March 2019Source: Biosensors and BioelectronicsAuthor(s): K.N. Brinda, Gautam Achar, Jan Grzegorz Małecki, Srinivasa Budagumpi, D.H. Nagaraju, V. Suvina, R. Geetha BalakrishnaAbstractGlucose oxidase mimicking nickel–based porous structures with organic anchors are developed as cheap and reliable electrochemical sensors for the quantitative detection of glucose. A series of sterically and electronically modulated, air– and moisture–stable half–sandwich nickel(II) NHC complexes were prepared and characterized. Under the optimized electrocatalytic conditions, the nickel complex immobilized glassy carbon electrodes (GCEs) displayed high sensitivity (0.663, 1.280, 1.990 and 0.182 μA/μM) towards glucose detection, which is much higher than that of 3D porous nickel networks. The limit of detection of modified GCEs is found in the range 1.56–2.09 μM with much wider linear sensing range, and having a catalytic rate constant of 0.273 × 103 M−1s−1. Finally, the selectivity of the modified GCEs towards glucose in presence of other blood constituents was also evaluated.

Source: Biosensors and Bioelectronics - March 29, 2019 Category: Biotechnology Source Type: research