IIG Seminar Series - Golnaz Vahedi (UPenn) - "Genetic predisposition to type 1 diabetes leads to chromatin misfolding"

Date: Wednesday, 03 27, 2019; Speaker: Golnaz Vahedi; Building: Building 10 (Clinical Center); Lipsett Auditorium; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events

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Publication date: Available online 15 August 2019Source: Life SciencesAuthor(s): Xuelian Li, Zhiyang Li, Bingong Li, Xianjie Zhu, Xingjun LaiAbstractAimsNLRP3 inflammasome activation is essential for the development and prognosis of diabetic cardiomyopathy (DCM). The anti-aging protein Klotho is suggested to modulate tissue inflammatory responses. The aim of the present study was to examine the protective effects of Klotho on DCM.Main methodsA streptozotocin-induced diabetes mouse model was established to assess the effects of Klotho in vivo, which was administered for 12 weeks. The characteristics of type 1 DCM were eva...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: 1 October 2019Source: Life Sciences, Volume 234Author(s): Catarina Marques, Andreia Gonçalves, Patrícia Manuela Ribeiro Pereira, Daniela Almeida, Beatriz Martins, Carlos Fontes-Ribeiro, Flávio Reis, Rosa FernandesAbstractAimsOxidative stress has been linked to the development and progression of diabetic nephropathy (DN). The present study evaluated whether the dipeptidyl peptidase-4 inhibitor sitagliptin attenuates glomerular lesions and oxidative stress evoked by chronic hyperglycemia, by a mechanism independent of insulin secretion and glycemia normalization.Main methodsA rat model ...
Source: Life Sciences - Category: Biology Source Type: research
M. Yassine For a long time, viruses have been shown to modify the clinical picture of several autoimmune diseases, including type 1 diabetes (T1D), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS), herpetic stromal keratitis (HSK), celiac disease (CD), and multiple sclerosis (MS). Best examples of viral infections that have been proposed to modulate the induction and development of autoimmune diseases are the infections with enteric viruses such as Coxsackie B virus (CVB) and rotavirus, as well as influenza A viruses (IAV), and herpesviruses. Other viruses that ...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
This study aimed to develop a short form of the Diabetes Acceptance and Action Scale that would be suitable for administration across all ages.MethodPeople with diabetes were recruited via social media, support organisations and charities as well as clinical services. They completed an online survey measuring demographic and clinical data, the Diabetes Acceptance &Action Scale, Problems in Diabetes Short Form, Self-Care Inventory Revised, Brief Experiential Avoidance Questionnaire, Cognitive Fusion Questionnaire and Engaged Living Scale.ResultsFive hundred and thirty-one participants with diabetes responded to the onli...
Source: Journal of Contextual Behavioral Science - Category: Psychiatry & Psychology Source Type: research
ConclusionOur data demonstrate that LMP limits T1D development by inducing caecal homeostasis to shape pancreatic immune environment, providing a scientific basis for using LMP as a novel functional supplementation to intervene T1D.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Food & Function Source Type: research
The Healthcare Quality Improvement Partnership has published the results of audits of insulin pump treatment for patients with type 1 diabetes and early intervention in psychosis.
Source: NHS Networks - Category: UK Health Source Type: news
Low-carbohydrate diet (LCD) has gained interest among individuals with diabetes as a means to manage glycaemia. We investigated the adherence to LCD in the Finnish Diabetic Nephropathy Study and whether carbohydrate restriction is associated with cardio-metabolic risk factors.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Hypertrophy and dysfunction of the urinary bladder are consistently observed in animal models of type 1 and less consistently in those of type 2 diabetes. We have tested the effects of mild hyperglycemia (n = 10 per group) in a randomized, blinded study and, in a blinded pilot study, of type 2 diabetes (n = 6 per group) and its treatment with dapagliflozin (1 mg/kg/day) on weight, contraction and relaxation of the rat bladder. Based on a combination of high-fat diet and a low dose of streptozotocin, animals in the main study reached a mean peak blood glucose level of about 300 mg/dl, which declined to 205 mg/dl at study en...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Diabetes Technology&Therapeutics, Ahead of Print.
Source: Diabetes Technology - Category: Endocrinology Authors: Source Type: research
Conclusion. These data demonstrate that DM may contribute to IDD by increasing aggrecan degradation and promoting cell apoptosis, which may represent early indicators of the involvement of DM in the pathogenesis of IDD. Level of Evidence: N/A
Source: Spine - Category: Orthopaedics Tags: BASIC SCIENCE Source Type: research
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