Characteristics of Waldenström Macroglobulinemia in Koreans According to Mutational Status of MYD88 and CXCR4: Analysis by Ultra-Deep Sequencing

ConclusionsThe frequency of MYD88/CXCR4 mutations in Korean and Caucasian patients with WM was similar, however 5 out of the 6 CXCR4 mutations were nonsense—a proportion higher than reported frequencies in Caucasians. Ultra-deep sequencing was capable of detecting CXCR4 mutations not detectable by Sanger sequencing, suggesting a possible replacement of the B-cell sorting.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research