The Efficacy of Systemic Doxycycline Administration as an Inhibitor of Intimal Hyperplasia after Balloon Angioplasty Arterial Injury

Intimal hyperplasia (IH) is the most common indicator for secondary intervention in peripheral vascular disease. Matrix metalloproteinases (MMPs) play a role in IH development due to their degradation of the extracellular matrix. Doxycycline (Doxy), a member of the tetracycline family of antibiotics, is a potent MMP inhibitor. We have previously shown that Doxy inhibits  MMP activity and vascular smooth muscle cell migration in vitro. We hypothesized that Doxy would decrease MMP activity in vivo and inhibit the development of IH in a rodent model of vascular injury.

Source: Annals of Vascular Surgery - January 23, 2019 Category: Surgery Authors: Deidra J.H. Mountain, Stacy S. Kirkpatrick, Joshua D. Arnold, M. Ryan Buckley, Michael M. McNally, Scott L. Stevens, Michael B. Freeman, Oscar H. Grandas Tags: Clinical Research Source Type: research