Bacterial sepsis triggers an antiviral response that causes translation shutdown

In response to viral pathogens, the host upregulates antiviral genes that suppress translation of viral mRNAs. However, induction of such antiviral responses may not be exclusive to viruses, as the pathways lie at the intersection of broad inflammatory networks that can also be induced by bacterial pathogens. Collectively, our findings imply that translation shutdown is indifferent to the specific initiating pathogen and is an important determinant of tissue injury in sepsis.

Source: Current Awareness Service for Health (CASH) - February 14, 2019 Category: Consumer Health News Source Type: news