Newlywed whose itchy skin was dismissed as an infection for years is battling cancer

Jade Whiston, 36 - of Pitsea, Essex - started itching uncontrollably in 2015, which would drive her to 'dig holes in herself' and leave her body covered in sores from her incessant scratching.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Conclusion: Cir_ITCH and circHIPK3 may have imperative roles in GC and serve in the future as potential prognostic biomarkers in GC. PMID: 30866608 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Grains can play havoc with your skin. The prolamin proteins, such as gliadin,  trigger autoimmune skin reactions and turn antibodies against the skin enzymes, their lectins fan the fires of inflammation, their proteins provoke allergies, and their amylopectins send blood sugar and insulin sky-high and provoke the skin-disrupting hormone insulin-like growth factor-1 (IGF). The whole grain package adds up to an impressive collection of skin conditions that can take a variety of forms, from simple red, itchy rashes to scaly, oily raised patches to large vesicles to gangrene. B...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates Source Type: blogs
Grains can play havoc with your skin. The prolamin proteins, such as gliadin,  trigger autoimmune skin reactions and turn antibodies against the skin enzymes, their lectins fan the fires of inflammation, their proteins provoke allergies, and their amylopectins send blood sugar and insulin sky-high and provoke the skin-disrupting hormone insulin-like growth factor-1 (IGF). The whole grain package adds up to an impressive collection of skin conditions that can take a variety of forms, from simple red, itchy rashes to scaly, oily raised patches to large vesicles to gangrene. B...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates Source Type: blogs
Jade Whiston, 36 - of Pitsea, Essex - started itching uncontrollably in 2015, which would drive her to 'dig holes in herself' and leave her body covered in sores from her incessant scratching.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: PRMT5 and PRMT1 mediate the distinct effects on CFLARL degradation by regulating the binding of E3 ligase ITCH in NSCLC cells. This study identifies a cell death mechanism that is fine-tuned by PRMT1/5 that modulate CFLARL degradation in human NSCLC cells. PMID: 30736843 [PubMed - in process]
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Tags: J Exp Clin Cancer Res Source Type: research
In conclusion, patients receiving EGFRIs suffer from severe pruritus frequently. They not only experienced long lasting and intense itching, causing sleep discomfort, but also developed itching at specific body sites. PMID: 30673106 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
CONCLUSIONS: Circ-ITCH suppresses cells proliferation and promotes cells apoptosis via sponging miR-10a in EOC cells. PMID: 30556849 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Introduction:Ocular graft-versus-host disease (GvHD) is a common complication of allogeneic hematopoietic stem cell transplantation (alloHSCT), typically affecting 40-60% of patients within 3 years after alloHSCT. The most common clinical manifestation is dry eye disease (DED), which may lead to secondary epithelial changes in the cornea such as filamentary keratitis, and contribute to ocular discomfort and further complications. Patients with DED typically require a complete ophthalmologic examination, including a slit lamp exam to look at punctate epithelial erosions (PEEs) and other ocular surface findings. Treatment fo...
Source: Blood - Category: Hematology Authors: Tags: 722. Clinical Allogeneic Transplantation: Acute and Chronic GVHD, Immune Reconstitution Source Type: research
Abstract Direct-acting a antiviral (DAA) are currently used in the treatment of chronic HCV infection. In patients with renal failure with Elbasvir/Grazoprevir (genotype 1 and 4) or Pibrentasvir/Glecaprevir (genotype 1-6) is advised and these documented both good safety and efficacy. In this manuscript we reported the development of cholestatic jaundice, during Pibrentasvir/Glecaprevir treatment, in a 86-year-old male with chronic HCV (genotype 2) infection and renal failure. At examination patient was jaundiced and suffered of a severe itch. Ultrasound and laboratory findings excluded a liver failure (e.g. liver ...
Source: Current Drug Safety - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Saf Source Type: research
Authors: Aki D, Li Q, Li H, Liu YC, Lee JH Abstract Protein ubiquitination is an important means of post-translational modification which plays an essential role in the regulation of various aspects of leukocyte development and function. The specificity of ubiquitin tagging to a protein substrate is determined by E3 ubiquitin ligases via defined E3-substrate interactions. In this review, we will focus on two E3 ligases, VHL and Itch, to discuss the latest progress in understanding their roles in the differentiation and function of CD4+ T helper cell subsets, the stability of regulatory T cells, effector function of...
Source: Protein and Cell - Category: Cytology Tags: Protein Cell Source Type: research
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