Gpihbp1 deficiency accelerates atherosclerosis and plaque instability in diabetic Ldlr-/- mice

Glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 (GPIHBP1) plays a crucial role in triglyceride hydrolysis, and GPIHBP1 deficiency leads to severe hypertriglyceridemia (HTG). Gpihbp1 knockout (GKO) mice develop mild lesions in the aortic root at the age of 11 months. Herein, we investigated the effect of Gpihbp1 deficiency on atherosclerosis (AS) under diabetic conditions.

Source: Atherosclerosis - January 28, 2019 Category: Cardiology Authors: Xuejing Liu, Jingyi Li, Jiawei Liao, Huan Wang, Xiaomin Huang, Zhao Dong, Qiang Shen, Ling Zhang, Yuhui Wang, Wei Kong, George Liu, Wei Huang Source Type: research