Pattern recognition receptors as potential therapeutic targets in metabolic syndrome: From bench to bedside

Publication date: Available online 18 January 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Amanda Almeida de Oliveira, Destiny Davis, Kenia Pedrosa NunesAbstractPattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) and NOD-like receptors (NLRs) play crucial roles in the underlying mechanisms of metabolic syndrome (MetS). Mainly, these receptors have been suggested to participate in the pathophysiological processes involved in the complications associated with this condition. Therefore, to evolve therapeutic strategies targeting PRRs might be an imperative approach to avoid the development of further complications in human subjects. In this work, we discuss the understanding regarding the roles of PRRs in the pathways of MetS to describe further the potential advancements made to target these receptors within this pathology.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research