Medical News Today: Does biotin help with psoriasis?

Some people use supplements of biotin, or vitamin B-7, to manage the symptoms of psoriasis. In this article, we look at the effectiveness, risks, and alternatives to biotin for psoriasis.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Psoriasis Source Type: news

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Publication date: 1 September 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 181Author(s): David Limón, Kirian Talló Domínguez, María Luisa Garduño-Ramírez, Berenice Andrade, Ana C. Calpena, Lluïsa Pérez-GarcíaAbstractSupramolecular hydrogels were synthesized using a bis-imidazolium based amphiphile, and incorporating chemically diverse drugs, such as the cytostatics gemcitabine hydrochloride and methotrexate sodium salt, the immunosuppressive drug tacrolimus, as well as the corticoid drugs betamethasone 17-valerate and triamcinolone acetonide, and th...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
CONCLUSIONS: During antihypertensive treatment, several dermatological reactions may occur. Clinicians should inform their patients of the increased risk of cutaneous lesions associated with the use of these drugs, and perform periodic examination of the skin. PMID: 31195782 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Authors: Teeple A, Muser E Abstract Aims: To estimate annual cost per response (CPR) in the US and number needed to treat (NNT) among subjects receiving guselkumab or adalimumab treatment for moderate to severe plaque psoriasis (PsO). Materials and methods: Results from VOYAGE 1, a double-blind, placebo-controlled, head-to-head, 48-week study of guselkumab compared with adalimumab in patients with moderate to severe PsO were used to estimate annual CPR for Psoriasis Area and Severity Index (PASI) 75, 90 and 100 responses. Drug dosing followed US label recommendations and drug costs were based on US annual whol...
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Psoriasis is the most common immune-mediated skin disease in adults (Lowes et al., 2014), in which the disturbed interplay between keratinocytes and immune cells leads to chronic skin inflammation (Lowes et al., 2014). Conventionally, keratinocytes were thought to be passive bystanders, however recent research suggests their active involvement in the disease (Lowes et al., 2014, Swindell et al., 2011). In psoriasis, keratinocytes acts as an amplifier of skin inflammation by producing antimicrobial peptides, cytokines and chemokines (Lowes et al., 2014).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research
Guselkumab selectively inhibits interleukin (IL)-23 and in psoriasis, produces high clinical responses including durable maintenance following treatment withdrawal in some patients. The relationships between IL-23 blockade, serum markers downstream of IL-23 signaling, and withdrawal were explored with guselkumab in VOYAGE 2.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
Authors: Li AA, Ahmed A, Kim D Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and encompasses a spectrum of pathology from simple steatosis to inflammation and significant fibrosis that leads to cirrhosis. NAFLD and its comorbid conditions extend well beyond the liver. It is a multisystemic clinical disease entity with extrahepatic manifestations such as cardiovascular disease, type 2 diabetes, chronic kidney disease, hypothyroidism, polycystic ovarian syndrome, and psoriasis. Indeed, the most common causes of mortality in subjects with NAFLD are cardiovascular disease, f...
Source: Gut and Liver - Category: Gastroenterology Tags: Gut Liver Source Type: research
Conclusion: This phase 1 study demonstrated favorable safety, tolerable toxicity, and preliminary efficacy of icotinib cream in patients with mild to moderate psoriasis. The dose concentration of 2.0% (twice daily based on the fingertip unit method) is recommended for further study. Study Design: This is a single-center, randomized, double-blind, and vehicle-controlled study. PMID: 31187048 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
AbstractIntroductionPsoriasis is estimated to affect 0.44 –2.8% of the Indian population. Moisturizers are a key adjuvant psoriasis treatment strategy, but data regarding their effectiveness, safety and compliance pattern in an Indian context are lacking. Hence, this real-world study on an intensive plant-based butter moisturizing cream (Venusia® Max) was conducted among Indian patients with psoriasis.MethodsThis was an observational, patient-reported outcomes (PRO) study in patients with psoriasis aged 18 –75 years who were prescribed the cream in routine clinical practice, as per clinician’s di...
Source: Dermatology and Therapy - Category: Dermatology Source Type: research
Conclusion: We demonstrated increased topical drug delivery of curcumin to inflamed tissues using HA-ES targeting the highly expressed CD44 protein. This innovative strategy could be applied for the development of topical drug delivery systems targeting inflamed skin.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Conclusion: Cathepsin B is actively involved in the effector phase of acute cutaneous DTHR. Thus, topically applied cathepsin B inhibitors might effectively limit DTHR such as contact dermatitis or psoriasis. However, the cathepsin B and Z knockout mouse experiments suggested a complementary role for these two cysteine-type proteases.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
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