Medical News Today: Does biotin help with psoriasis?
Some people use supplements of biotin, or vitamin B-7, to manage the symptoms of psoriasis. In this article, we look at the effectiveness, risks, and alternatives to biotin for psoriasis.
Condition: Plaque Psoriasis Interventions: Biological: Adalimumab originator; Biological: Adalimumab biosimilar Sponsor: Alvotech Swiss AG Not yet recruiting
Authors: Markova ND Abstract The current review provides data and focuses on blood as a niche for the presence of cell wall-deficient microbes (L-forms). The hypothesis for the existence of L-form microbiota in humans was tested by us using an innovative methodology for the isolation of L-form cultures from human blood. Criteria were conceived for the individual assessment of blood microbiota and recognition of two types of states -- "eubiotic" and "dysbiotic" blood microbiota. Cell wall-deficient microbes (CWD) that inhabit blood in healthy people are in natural balance with the host homeostasi...
This study aims to understand the systemic component of psoriasis pathogenesis since psoriasis patients have higher risk of developing diesases beyond skin inflammation. In this study, we collected sigmoidal gut biopsies to profile host transcriptomic changes associated with psoriasis patients and healthy subjects. This exepriment provided transcriptomic dataset of host response and is integrated with fecal metagenomic data and flow cytometry dataset as part of the multi-omic study.
AbstractStratified medicine is the tailoring of treatment to the individual characteristics of each patient. This is a challenging task in the context of psoriasis, a complex disease with a variety of phenotypic presentations and a comorbidity burden that extends beyond cutaneous manifestations. In recent years, considerable progress has been made in understanding the immunology of psoriasis, and this has informed the development of increasingly precise and efficacious therapies. However, not all patients respond to biologic therapy, and access is limited to patients with moderate to severe disease. However, sub...
Happify Health, known for its digital mental health programs, today released a platform targeted towards people with chronic conditions, called Kopa. The first component of this new platform is Kopa for Psoriasis, a product created to provide resources and community for those living with the condition. The company chose to first focus on psoriasis because of the c omorbidities often associated with it, such as stress, depression, anxiety, self-consciousness and impaired social functioning. WHAT’S THE IMPACT?
Clinical Trial Examines Human Micro-biome-based Drug SFA002 In Mild to Moderate Plaque Psoriasis PHILADELPHIA, June 29, 2020 -- (Healthcare Sales &Marketing Network) -- SFA Therapeutics, Inc. is pleased to announce that the US FDA has provided approva... Biopharmaceuticals, Dermatology SFA Therapeutics, psoriasis, microbiome
To investigate how theCARD14E138A psoriasis-associated mutation induces skin inflammation, a knock-in mouse strain was generated that allows tamoxifen-induced expression of the homologousCard14E138A mutation from the endogenous mouseCard14 locus. Heterozygous expression of CARD14E138A rapidly induced skin acanthosis, immune cell infiltration and expression of psoriasis-associated pro-inflammatory genes. Homozygous expression of CARD14E138A induced more extensive skin inflammation and a severe systemic disease involving infiltration of myeloid cells in multiple organs, temperature reduction, weight loss and organ failure. T...
CONCLUSION: Courrently approved novel biologic therapies for moderate to severe psoriasis revealed an increasing effectivness compared to previous biological therapy and a good safety profile. PMID: 32598253 [PubMed - as supplied by publisher]