Are CT lung screening trials underestimating harms?

The complication rates and subsequent costs of invasive diagnostic procedures...Read more on AuntMinnie.comRelated Reading: CT lung cancer screening foiled by low adherence Lung cancer overdiagnosis varies widely on CT screening Annals: Overdiagnosis must be better defined Risk-based CT lung screening could be more efficient ARRS: Do NLST results translate to the real world?
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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The U.S. Food and Drug Administration (FDA) has granted 510(k) clearance to...Read more on AuntMinnie.comRelated Reading: Canon debuts Alphenix version for labs and centers Canon plans to open Middle East division Canon unveils Alphenix Encore Plus Program Canon's CT portfolio primed for lung cancer screening Canon installs 3T MRI scanner in Colo.
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
This study aimed to assess physical function and HRQOL of MPM patients following pleurectomy/decortication (P/D) in the convalescent phase.MethodsThe study included 16 male MPM patients who underwent P/D between September 2014 and August 2016. Physical function was assessed based on handgrip and knee extensor strengths, the six-minute walk distance (6MWD), and pulmonary function, including forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). HRQOL was assessed using the Medical Outcome Study 36-item Short Form Health Survey (SF-36). The assessment was performed preoperatively, postoperatively, and...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Publication date: February 2020Source: Materials Science and Engineering: C, Volume 107Author(s): Mehak Passi, Vinay Kumar, Gopinath PackirisamyAbstractMultifunctional nanomaterials integrating therapeutic and imaging modalities in one platform have opened a new era in the present therapeutic strategies. In the present study, a multifunctional silk fibroin-based carrier has been designed for the delivery of antioxidant and imaging agents. One-step desolvation method was used to prepare sulforaphane (antioxidant drug) loaded silk fibroin nanoparticles (SFSNPs). These anionic SFSNPs were further coupled with cationic cerium ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
If you're a smoker and want to cut your chances of dying from cancer by smoking...Read more on AuntMinnie.comRelated Reading: CDC names vaping-related illness, issues new guidance Do CT lung screening rules overlook first responders? Risk model improves accuracy of CT lung cancer screening Demographic factors limit access to CT lung screening CT lung screening's benefits persist over time
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Dr Tony Mok of Hong Kong University reviews key studies on non-small cell lung cancer therapies, presented at the 2019 annual meeting of the European Society for Medical Oncology (ESMO).Medscape
Source: Medscape Today Headlines - Category: Consumer Health News Tags: None ReCAP Source Type: news
A liquid biopsy may be able to predict the efficacy of EGFR-targeted tyrosine kinase inhibitors in patients with non –small cell lung cancer.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Conclusion: Our findings identify PTC-209 as a promising anticancer agent for the treatment of solid tumors either alone and/or in combination with the standard cytotoxic drugs cisplatin and camptothecin and the natural product Frondoside-A.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
We present a step-by-step computational protocol for functional gene expression analysis and the identification of diagnostic and prognostic signatures by combining meta-analysis with machine learning and survival analysis. The novelty of the toolbox lies in its all-in-one functionality, generic design, and modularity. It is exemplified for lung cancer, including a comprehensive evaluation using different validation strategies. However, the protocol is not restricted to specific disease types and can therefore be used by a broad community. The accompanying R package vignette runs in ~1 h and describes the workflow in detai...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
les Ricordel Non-small cell lung cancer (NSCLC) has been the leading cause of cancer-related death worldwide, over the last few decades. Survival remains extremely poor in the metastatic setting and, consequently, innovative therapeutic strategies are urgently needed. Inhibitor of Growth Gene 2 (ING2) is a core component of the mSin3A/Histone deacetylases complex (HDAC), which controls the chromatin acetylation status and modulates gene transcription. This gene has been characterized as a tumor suppressor gene and its status in cancer has been scarcely explored. In this review, we focused on ING2 and other mSin3A/HDAC ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
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