Pirfenidone in RAS After Lung Transplantation Pirfenidone in RAS After Lung Transplantation
How might pirfenidone benefit lung transplant recipients with restrictive allograft syndrome?American Journal of Transplantation
Exosomes isolated from plasma of lung transplant recipients (LTxRs) with bronchiolitis obliterans syndrome (BOS) contain human leukocyte antigens and lung self-antigens (SAgs), K-alpha 1 Tubulin (K α1T) and Collagen-V (Col-V). The aim was to determine the use of circulating exosomes with lung SAgs as a biomarker for BOS.
Conclusion: These findings suggest that Tubastatin A downregulates Th17 cell function and suppresses acute lung allograft rejection, at least partially, via the HIF-1α/ RORγt pathway.
The continued shortage of donor organs, together with a sustained increase in the number of potential donors with hepatitis C virus (HCV) infection (related to the ongoing opioid epidemic) and the advent of direct acting antiviral agents(DAA), has led to increased utilization of HCV-positive donors for heart transplantation(HT) (1). Furthermore, multiple recent studies have shown that 1-year HT-survival using HCV-positive donors in the current era of DAAs is similar to HT-survival using non-HCV donors (1,2).
Abstract PURPOSE OF REVIEW: Nocardia is a ubiquitous pathogen associated with life-threatening opportunistic infections. Organ transplant recipients are uniquely predisposed to Nocardia infections due to their iatrogenic cell-mediated immune deficit necessary to maintain allograft function. This review aims to address recent updates in the epidemiology, clinical presentation, diagnostics, treatment, and outcomes of Nocardia infections in solid-organ transplant recipients. RECENT FINDINGS: The incidence of Nocardia infection depends on multiple patient and environmental factors. Among transplant recipients, lu...
In this study, we investigated the efficacy of mitochondrial transplantation to enhance myocardial function of DCD hearts.
This study aimed to verify the hypothesis that the application of dexmedetomidine during the perioperative period of liver transplantation can reduce the incidence of EAD and primary graft non-function (PNF). At the same time, the effects of dexm edetomidine application on perioperative renal function and lung function were studied.MethodsThis is a prospective, single-center, randomized, parallel-group study. Two hundred participants (18 –65 years) scheduled to undergo liver transplantation under general anesthesia will be included in this study. For participants in the treatment group, a loading dose of DEX w...
Authors: Ghaidan H, Fakhro M, Lindstedt S Abstract Purpose: The influence of allograft ischemic time (IT) on short- and long-term mortality remains under debate in lung transplantation (LTx). Due to a scarcity in donors, better understanding of IT might improve the outcome after LTx. Methods: Between January 1990 and June 2016; 307 patients underwent LTx at Lund university hospital, Sweden. The end-point used was death/Re-LTx assessed by Cox regression and Kaplan-Meier survival. Results: Kaplan-Meier survival for mean IT (min) between subgroups ≤120, 121-240, 241-360 and 361+ showed significant difference for pa...
Since the inception of lung transplantation, serial pulmonary function testing (PFT) has been key to quantifying allograft health. In 1993 an International Society for Heart and Lung Transplantation (ISHLT) consensus report standardized the approach to using PFT measures to benchmark lung allograft function1. Specifically chronic graft dysfunction, or bronchiolitis obliterans syndrome (BOS), was suggested by a sustained ≥20% decline in forced expiratory volume in 1 second (FEV1) as compared to the average of the two best posttransplant FEV1s measured at least three weeks apart in the absence of evident confounders1.
: Circulating extracellular vesicles (EV) are raising considerable interest as a non-invasive diagnostic tool as they are easily detectable in biological fluids and contain specific set of nucleic acids, proteins, and lipids reflecting pathophysiological conditions. We aimed to investigate differences in plasma-derived EV surface-protein profile as biomarker to be used in combination with endomyocardial biopsies (EMB) for the diagnosis of allograft rejection.
CONCLUSIONS: These findings demonstrate that telomere dysfunction isolated to airway epithelial cells leads to airway-centric lung remodeling and fibrosis similar to that observed in patients with CLAD and suggest that lung epithelial cell telomere dysfunction may be a molecular driver of CLAD. PMID: 32551854 [PubMed - as supplied by publisher]