Pirfenidone in RAS After Lung Transplantation Pirfenidone in RAS After Lung Transplantation

How might pirfenidone benefit lung transplant recipients with restrictive allograft syndrome?American Journal of Transplantation
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Transplantation Journal Article Source Type: news

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Publication date: Available online 21 June 2019Source: The Annals of Thoracic SurgeryAuthor(s): Karina Loor, Mario Culebras, Irene Sansano, Antonio Álvarez, Cristina Berastegui, Javier de GraciaAbstractBackgroundPrevious studies suggest that transbronchial lung biopsy using a cryoprobe is superior to transbronchial lung biopsy using forceps for evaluating lung grafts; however, the technique can be associated an increase in complications. Since cryoprobe experience is limited, assessment of a greater number of cases is warranted. This prospective study evaluates the diagnostic yield, complications and risk factors as...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ConclusionsIn preadolescent children undergoing PLTx, size mismatching is associated with increased death. Our findings differ from studies in adults, which demonstrated improved survival associated with oversized allografts. Accordingly, well-matched allografts should be prioritized when assessing donor-recipient pairs for transplantation.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
cia J Abstract BACKGROUND: Previous studies suggest that transbronchial lung biopsy using a cryoprobe is superior to transbronchial lung biopsy using forceps for evaluating lung grafts; however, the technique can be associated an increase in complications. Since cryoprobe experience is limited, assessment of a greater number of cases is warranted. This prospective study evaluates the diagnostic yield, complications and risk factors associated with the cryoprobe technique. METHODS: From April 2013 to April 2016, 321 consecutive cryoprobe transbronchial biopsies were indicated in single or bilateral lung transp...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
It is recognized donor factors contribute to lung transplant outcomes. Recent observations and studies have started to elucidate potential mechanisms behind explaining these observations. This perspective piece summarizes evolving lung transplant literature on the subject, focussing on donor ‘passenger’ organisms, cells, hormones and proteins transferred to the recipient. Many extrinsic and intrinsic donor features or properties have important consequences for subsequent allograft function in the recipient.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Perspective Source Type: research
In patients awaiting heart transplantation (HTx), end-stage disease of a second organ may occasionally require consideration of simultaneous multiorgan transplantation. As cardiac and renal disease are related physiologically and often co-exist, the population of combined heart and kidney transplantation (HKTx) has significantly increased over the last few years along with the growing number of patients wait listed for heart.1,2 Interestingly, short-term survival rates after HKTx have been reported to be comparable to those after isolated HTx.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Alterations in the partly microbiota-dependent carnitine-butyrobetaine ( γBB)- trimethylamine-N-oxide (TMAO) pathway have been linked to the progression of heart failure and atherosclerotic disease. We evaluated if circulating γBB, TMAO and their common precursors carnitine and trimethyllysine (TML) were dysregulated after heart transplantation and associated with deve lopment of cardiac allograft vasculopathy (CAV) and acute rejection.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
This study aimed to investigate whether FCGR2A and FCGR3A polymorphisms can also be associated with the clinical outcome of lung transplant recipients (LTRs). The SNPs of FCGR2A ([131R/H], rs1801274) and FCGR3A ([158V/F], rs396991) were identified in 158 LTx recipients (LTR) and 184 Controls (CTL). The corresponding distribution of genotypic and allelic combinations was analyzed for potential links with the development of circulating donor-specific anti-HLA alloantibodies (DSA) detected at months 1 and 3 after lung transplant (LTx), the occurrence of acute rejection (AR) and chronic lung allograft dysfunction (CLAD), and...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Background. Smoking remains the leading cause of preventable disease and death in the developed world that kills half of all long-term users. Tobacco use after solid organ transplantation is associated with allograft dysfunction, cancer, and reduced overall survival. Methods. In this single-center, retrospective study, we describe the frequency of tobacco use after lung transplantation (LTx), pretransplant patient characteristics associated with tobacco use, and the safety, efficacy, and outcomes of posttransplant tobacco cessation interventions. Results. Four percent of our LTx cohort resumed tobacco use posttrans...
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
The advent of direct-acting antivirals (DAAs) in 2014 has transformed the landscape of hepatitis C virus (HCV) treatment, allowing patients to achieve cure after 8 to 12  weeks of safe and well-tolerated therapy.1 Because of the already limited organ donor pool and the availability of high numbers of HCV-viremic donors resulting from the opioid epidemic, this development has led to immense interest in transplanting organs from HCV-viremic donors into nonviremic rec ipients.2 In 2017, the first pilot of 10 noninfected patients who received kidney transplants from HCV-viremic donors demonstrated excellent allograft and ...
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Case Report Source Type: research
Abstract PURPOSE OF REVIEW: Lung transplantation has become an accepted therapy in infants, children, and adolescents suffering from end-stage lung diseases, an impaired quality of life and reduced life expectancy. The aim of this review is to highlight specific aspects of pediatric lung transplantation and to give an update on recent findings. RECENT FINDINGS: Currently, over 100 lung transplant procedures are performed in children annually worldwide. Long-term success is limited by availability of donor organs and waitlist mortality pretransplant, and an increased infection risk because of immunosuppression...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
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