Regiodivergent Hydroaminoalkylation of Alkynes and Allenes via a Combined Rhodium and Photoredox Catalytic System.

Regiodivergent Hydroaminoalkylation of Alkynes and Allenes via a Combined Rhodium and Photoredox Catalytic System.
Angew Chem Int Ed Engl. 2019 Jan 08;:
Authors: Breit B, Zheng J
Abstract
A rhodium/photoredox dual catalyzed regiodivergent α-allylation of amines is described. As an atom-economic and efficient method, alkynes and allenes are used as allylic electrophile surrogates in this novel protocol. With different reaction conditions, synthetic useful branched or linear homoallylic amines could be synthesized in good to excellent yields and regioselectivity. This straightforward strategy complements the traditional transition-metal catalyzed allylation reactions.
PMID: 30620131 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - January 8, 2019 Category: Chemistry Authors: Breit B, Zheng J Tags: Angew Chem Int Ed Engl Source Type: research