Cu-Mediated Aminoquinoline-Directed Radiofluorination of Aromatic C-H Bonds with K ¹⁸F.

Cu-Mediated Aminoquinoline-Directed Radiofluorination of Aromatic C-H Bonds with K¹⁸F.
Angew Chem Int Ed Engl. 2019 Jan 03;:
Authors: Lee SJ, Makaravage KJ, Brooks AF, Scott P, Sanford MS
Abstract
This communication describes a Cu-mediated ortho-C-H radiofluorination of aromatic carboxylic acids that are protected as 8-aminoquinoline benzamides. The method uses K¹⁸F and is compatible with a wide range of functional groups. The reaction is showcased in the high specific activity automated synthesis of the RARβ2 agonist [¹⁸F]AC261066.
PMID: 30605563 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - January 3, 2019 Category: Chemistry Authors: Lee SJ, Makaravage KJ, Brooks AF, Scott P, Sanford MS Tags: Angew Chem Int Ed Engl Source Type: research