Adalimumab treatment for psoriasis - safety in numbers.
Adalimumab treatment for psoriasis - safety in numbers. Br J Dermatol. 2019 Jan;180(1):14-15 Authors: Ryan C PMID: 30604539 [PubMed - in process]
CBD OIL has been billed as the next big solution for a wide-range of health conditions. Findings suggest the active ingredient could be useful for treating a certain symptom associated with skin conditions such as eczema and psoriasis.
Authors: Reich K, Foley P, Han C, McElligott S, Muser E, Li N, Armstrong AW Abstract Purpose: To evaluate the impact of guselkumab on work productivity, including absenteeism and presenteeism, in psoriasis patients with and without depression/anxiety. Methods: VOYAGE 2 is a randomized, double-blind, placebo-controlled, and comparator-controlled, phase 3 trial that compared guselkumab with adalimumab in patients with moderate-to-severe psoriasis. Absenteeism was evaluated among patients who reported that their skin prevented work/study based on the Dermatology Life Quality Index (DLQI) work/study domain (score = 3) ...
Conclusions: The prevalence of comorbidities and high rate of IMM prescriptions demonstrate the impact of AD on quality of life. The frequency of OCS prescribing in AD patients treated with IMMs suggests a lack of disease control with existing therapies, and an unmet need for safe and effective targeted agents for long-term disease control. PMID: 31305182 [PubMed - as supplied by publisher]
AbstractPsoriasis involving the genital skin occurs in up to two-thirds of psoriasis patients but is often overlooked by physicians. Furthermore, psoriasis objective and subjective severity indexes for common plaque psoriasis often neglect the impact this small area of psoriasis can have on a patient. It can have a significant impact on patients ’ psychosocial function due to intrusive physical symptoms such as genital itch and pain, and a detrimental impact on sexual health and impaired relationships. The mainstay of treatment is topical therapy. In patients with genital psoriasis refractory to traditional topical t...
A 42-year-old man presents with a 2-month history of persistent muscle twitching in his abdomen and bilateral calves during wakefulness and sleep accompanied with excessive sweating, as well as mild bilateral lower extremity weakness after prolonged walking. What is your diagnosis?
Authors: Kong Y, Zhang S, Su X, Peng D, Su Y Abstract Background: YKL-40, also named chitinase-3-like protein 1, has been confirmed as an inflammatory glycoprotein associated with cardiovascular disease, diabetes or metabolic syndrome which are common comorbidities in psoriasis. Growing evidence have demonstrated that serum levels of YKL-40 in psoriatic patients were increased, however, the results were appearance contradictory among the current published studies. Methods: Research involved in serum levels of YKL-40 in psoriatic patients and healthy control individuals were searched in PUBMED, EMBASE and The Cochra...
We present a case of E. rhusiopathiae mitral valve endocarditis in a farmer with psoriasis presented with acute intractable heart failure requiring valve replacement surgery. E. rhusiopathiae was identified by 16S rRNA-based gene sequencing from culture-negative, surgically excised mitral valve leaflets.
Conditions: Rheumatoid Arthritis; Polyarticular Juvenile Idiopathic Arthritis; Psoriatic Arthritis; Ankylosing Spondylitis; Crohn Disease; Ulcerative Colitis; Plaque Psoriasis; Pediatric Plaque Psoriasis; Pediatric Crohns Disease; Hidradenitis Suppurativa; Non-inf ectious Uveitis Intervention: Drug: 40 mg MSB11022 Sponsors: Fresenius Kabi SwissBioSim GmbH; PRA Health Sciences Not yet recruiting
In conclusion, encapsulation of celastrol by niosomes increased the water-solubility and permeation of celastrol into the skin, significantly improving its anti-psoriasis activity in mice.Graphical abstract