Increased risk of death in patients with psoriasis: disease or lifestyle?

Increased risk of death in patients with psoriasis: disease or lifestyle? Br J Dermatol. 2019 Jan;180(1):3-4 Authors: Danielsen K PMID: 30604549 [PubMed - in process]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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xue Kuang Psoriasis is an immune-mediated inflammatory dermatosis characterized by epidermal hyperplasia and excessive infiltration of inflammatory cells. Withanolides, extracted from Datura metel L.; are the main effective components for the treatment of psoriasis. However, the precise mechanisms of action of withanolides for the treatment of psoriasis remain unclear. We found that treatment with withanolides alleviated imiquimod (IMQ)-induced epidermal hyperplasia and inflammatory cell infiltration in the effective skin of model mice. In addition, we also found that withanolides suppressed the activation of STAT3, ER...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
CBD OIL has been billed as the next big solution for a wide-range of health conditions. Findings suggest the active ingredient could be useful for treating a certain symptom associated with skin conditions such as eczema and psoriasis.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Reich K, Foley P, Han C, McElligott S, Muser E, Li N, Armstrong AW Abstract Purpose: To evaluate the impact of guselkumab on work productivity, including absenteeism and presenteeism, in psoriasis patients with and without depression/anxiety. Methods: VOYAGE 2 is a randomized, double-blind, placebo-controlled, and comparator-controlled, phase 3 trial that compared guselkumab with adalimumab in patients with moderate-to-severe psoriasis. Absenteeism was evaluated among patients who reported that their skin prevented work/study based on the Dermatology Life Quality Index (DLQI) work/study domain (score = 3) ...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Conclusions: The prevalence of comorbidities and high rate of IMM prescriptions demonstrate the impact of AD on quality of life. The frequency of OCS prescribing in AD patients treated with IMMs suggests a lack of disease control with existing therapies, and an unmet need for safe and effective targeted agents for long-term disease control. PMID: 31305182 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
AbstractPsoriasis involving the genital skin occurs in up to two-thirds of psoriasis patients but is often overlooked by physicians. Furthermore, psoriasis objective and subjective severity indexes for common plaque psoriasis often neglect the impact this small area of psoriasis can have on a patient. It can have a significant impact on patients ’ psychosocial function due to intrusive physical symptoms such as genital itch and pain, and a detrimental impact on sexual health and impaired relationships. The mainstay of treatment is topical therapy. In patients with genital psoriasis refractory to traditional topical t...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
Homœopathic Links 2019; 32: 064-076 DOI: 10.1055/s-0039-1693403 Psoriasis is a chronic, non-contagious, autoimmune disease. A case series of five patients successfully treated by homoeopathy is presented herewith to acquaint the homoeopathic professionals about the effectiveness of single individualised constitutional homoeopathic medicine in the treatment of psoriasis. [...] Thieme Medical and Scientific Publishers Private Ltd. Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Homoeopathic Links - Category: Complementary Medicine Authors: Tags: Original Article Source Type: research
A 42-year-old man presents with a 2-month history of persistent muscle twitching in his abdomen and bilateral calves during wakefulness and sleep accompanied with excessive sweating, as well as mild bilateral lower extremity weakness after prolonged walking. What is your diagnosis?
Source: JAMA Neurology - Category: Neurology Source Type: research
Authors: Kong Y, Zhang S, Su X, Peng D, Su Y Abstract Background: YKL-40, also named chitinase-3-like protein 1, has been confirmed as an inflammatory glycoprotein associated with cardiovascular disease, diabetes or metabolic syndrome which are common comorbidities in psoriasis. Growing evidence have demonstrated that serum levels of YKL-40 in psoriatic patients were increased, however, the results were appearance contradictory among the current published studies. Methods: Research involved in serum levels of YKL-40 in psoriatic patients and healthy control individuals were searched in PUBMED, EMBASE and The Cochra...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
We present a case of E. rhusiopathiae mitral valve endocarditis in a farmer with psoriasis presented with acute intractable heart failure requiring valve replacement surgery. E. rhusiopathiae was identified by 16S rRNA-based gene sequencing from culture-negative, surgically excised mitral valve leaflets.
Source: IDCases - Category: Infectious Diseases Source Type: research
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
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