JAMA 2013-10-04, Vol. 310, No. 15, Audio from Weekly Author Video Interview

Interview with Anthony D. Harris, MD, author of Universal Glove and Gown Use and Acquisition of Antibiotic-Resistant Bacteria in the ICU: A Randomized Trial
Source: JAMA Author Interviews - Category: Journals (General) Authors: Source Type: podcasts

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CONCLUSION: There is a high prevalence of MRSA causing abscesses in the Hispanic population evaluated in an ED in Puerto Rico. Systemic antibiotic use for the treatment of skin abscesses after incision and drainage remains high despite published guidelines arguing against their widespread use. Clindamycin resistance in our patient population appears to be more frequent than previously reported. PMID: 33031694 [PubMed - as supplied by publisher]
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
U.S. Centers for Disease Control and Prevention officials announced Friday what they describe as a " national action plan " to fight antibiotic-resistant infections.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
The difference in sequential organ failure assessment (SOFA) scores from the baseline to sepsis is a known predictor of sepsis-3 outcome, but the prognostic value of drug-resistant organisms for mortality is unexplained. We employed sepsis stewardship and herein report an observational study. Study subjects were patients admitted to the Departments of Surgery/Chest Surgery from 2011 through 2018 with a diagnosis of sepsis and a SOFA score of 2 or more. Our sepsis stewardship methods included antimicrobial and diagnostic stewardship and infection control. We determined the primary endpoint as in-hospital death and the secon...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Authors: Saxena D, Kaul G, Dasgupta A, Chopra S Abstract Acute bacterial skin and skin structure infections (ABSSSIs) are one of the most common types of infections due to methicillin-resistant Staphylococcus aureus (MRSA). The standard of care for ABSSSI includes glycopeptides such as vancomycin, teicoplanin, oxazolidinones and fluoroquinolones, which are potent broad-spectrum antibacterial agents. Unfortunately, due to indiscriminate utilization, resistance to these agents is rising and identification of novel agents is an urgent unmet medical need. In this context, levonadifloxacin (WCK-771) is a novel, hydrate ...
Source: Drugs of Today - Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research
Single cell microorganisms including pathogens relentlessly face myriads of physicochemical stresses in their living environment. In order to survive and multiply under such unfavorable conditions, microbes have evolved with complex genetic networks, which allow them to sense and respond against these stresses. Stringent response is one such adaptive mechanism where bacteria can survive under nutrient starvation and other related stresses. The effector molecules for the stringent response are guanosine-5'-triphosphate 3'-diphosphate (pppGpp) and guanosine-3', 5'-bis(diphosphate) (ppGpp), together called (p)ppGpp. These eff...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Biofilms pose a relevant factor for wound healing impairment in chronic wounds. With 78% of all chronic wounds being affected by biofilms, research in this area is of high priority, especially since data for evidence-based selection of appropriate antimicrobials and antiseptics is scarce. Therefore, the objective of this study was to evaluate the anti-biofilm efficacy of commercially available hypochlorous wound irrigation solutions compared to established antimicrobials. Using an innovative complex in-vitro human plasma biofilm model (hpBIOM), quantitative reduction of Pseudomonas aeruginosa, Staphylococcus aureus, and Me...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
(Virginia Tech) With a $1.3 million grant from the National Science Foundation, researchers will build a cyberinfrastructure system, known as CI-WARS, for monitoring wastewater treatment plants for possible antibiotic resistance outbreak over time.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Publication date: December 2020Source: Microbial Pathogenesis, Volume 149Author(s): Tayyab ur Rehman, Rizwan Aslam, Amjad Islam Aqib, Mashkoor Mohsin, Asad Manzoor, Muhammad Shoaib, Muhammad Aamir Naseer, Ali Hasan, Huma Sattar, Muhammad Fakhar-e-Alam Kulyar, Iqra Muzammil, Wangyuan Yao
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Cover of Pathways student magazine. NIGMS and Scholastic bring you our latest issue of Pathways, which focuses on superbugs—infectious microbes that can’t be fought off with medicines. Viruses that can’t be prevented with vaccines, such as the common cold, and antibiotic-resistant bacteria both fall into this category. Pathways, designed for students in grades 6 through 12, is a collection of free resources that teaches students about basic science and its importance to health, as well as exciting research careers. The superbug issue will provide information about: Differences between bacteria a...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - Category: Research Authors: Tags: Being a Scientist Injury and Illness Bacteria Drug Resistance Infectious Diseases Medicines Viruses Source Type: blogs
Abstract Quaternary ammonium compounds (QACs) comprise a large class of surfactants, consumer products, and disinfectants. The recently-isolated QAC natural product tricepyridinium bromide displays potent inhibitory activity against S. aureus but due to its unique structure, its mechanism of action remains unclear. A concise synthetic route to access tricepyridinium analogs was thus designed and four N-alkyl compounds were generated in addition to the natural product. Biological analysis of these compounds revealed that they display remarkable selectivity towards clinically-relevant Gram-positive bacteria exceedin...
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research
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