Evaluation of matrix effects in quantifying microbial secondary metabolites in indoor dust using ultra performance liquid chromatograph-tandem mass spectrometer

ConclusionWe found that dust MEs resulted in substantial underestimation in quantifying MSMs and that DOM was not an optimal universal ISTD for the adjustment, but that the MMC method resulted in more accurate and precise recovery compared to DOM. More research on adjustment methods for dust MEs in the simultaneous analyses of multiple microbial secondary metabolites using LC-MSMS is warranted.

Source: Safety and Health at Work - December 21, 2018 Category: Occupational Health Source Type: research