Indivior plans cheaper opioid addiction drug to keep copycats at bay
Indivior Plc said it will launch a cheaper version of its blockbuster opioid addiction treatment, Suboxone, as it seeks to claw back market share lost to copycat versions of the drug.
Publication date: Available online 22 June 2019Source: Best Practice &Research Clinical HaematologyAuthor(s): Gregorio Barilà, Giulia Calabretto, Antonella Teramo, Cristina Vicenzetto, Vanessa Rebecca Gasparini, Gianpietro Semenzato, Renato ZambelloAbstractLarge Granular Lymphocyte Leukemia (LGLL) is a rare chronic lymphoproliferative disorder characterized by the clonal expansion of Large Granular Lymphocytes (LGLs). Among LGLL, the 2016 WHO classification recognizes two different entities, i.e. T-LGLL and the provisional entity Chronic Lymphoproliferative disorder of NK cells (CLPD-NK). In both subtypes neutro...
The first NHS gambling clinic for children will open this year, as part of a new network of services for addicts being rolled out as part of the NHS Long Term Plan.
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Publication date: Available online 23 June 2019Source: Redox BiologyAuthor(s): Diego G. Ogando, Moonjung Choi, Rajalekshmy Shyam, Shimin Li, Joseph A. BonannoAbstractSLC4A11 is a NH3 sensitive membrane transporter with H+ channel-like properties that facilitates Glutamine catabolism in Human and Mouse corneal endothelium (CE). Loss of SLC4A11 activity induces oxidative stress and cell death, resulting in Congenital Hereditary Endothelial Dystrophy (CHED) with corneal edema and vision loss. However, the mechanism by which SLC4A11 prevents ROS production and protects CE is unknown. Here we demonstrate that SLC4A11 is localiz...
E-cigarettes and tobacco products contain an addictive drug called nicotine, which makes it very hard to stop using them.Read More »
Jack Richie started gambling at school and took his own life at 24. His parents say the addiction is 'not unlike a heroin addiction'.
The first National Problem Gambling Clinic, offering support to people aged 13 to 25, is set to open.
The first NHS gambling clinic for children will open this year as part of a new network of services for addicts being rolled out as part of the NHS Long Term Plan.
Conclusion: The concomitant use of nicotine and areca indicates that betel quid addiction includes a significant component of nicotine dependence. However, the additional activities of areca, including the muscarinic effects of arecoline, indicate that potential cessation therapies should optimally address other factors as well. PMID: 31220988 [PubMed - as supplied by publisher]