Deletion of OPN in BSP knockout mice does not correct bone hypomineralization but results in high bone turnover

The two SIBLING (Small Integrin Binding Ligand N-linked Glycoproteins), bone sialoprotein (BSP) and osteopontin (OPN) are expressed in osteoblasts and osteoclasts. In mature BSP knockout (KO, −/−) mice, both bone formation and resorption as well as mineralization are impaired. OPN−/− mice display impaired resorption, and OPN is described as an inhibitor of mineralization. However, OPN is overexpressed in BSP−/− mice, complicating the understanding of their phenotype. We have generated and characterized mice with a double KO (DKO) of OPN and BSP, to try and unravel their respective contributions.

Source: Bone - December 4, 2018 Category: Orthopaedics Authors: W. Bouleftour, L. Juignet, L. Verdi ére, I. Machuca-Gayet, M. Thomas, N. Laroche, A. Vanden-Bossche, D. Farlay, C. Thomas, E. Gineyts, J.P. Concordet, J.B. Renaud, D. Aubert, M. Teixeira, O. Peyruchaud, L. Vico, M.H. Lafage-Proust, H. Follet, L. Malaval Tags: Full Length Article Source Type: research