5-Fluorouracil and Capecitabine: Assessment and Treatment of Uncommon Early-Onset Severe Toxicities Associated With Administration.

This article delineates the differences between expected side effects and uncommon early-onset severe toxicities from 5-FU and capecitabine. It also provides background for understanding the reasons patients may develop these toxicities and reviews the efficacy of standard supportive care against a novel therapy (uridine triacetate). METHODS: A panel of nurses convened to review the literature about toxicities associated with 5-FU and capecitabine administration and determined methods to educate nurses about toxicities and treatment. FINDINGS: Standard supportive care for 5-FU and capecitabine toxicities is associated with high fatality rates. Uridine triacetate treatment within 96 hours of administration is associated with survival. PMID: 30451997 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/30451997?dopt=Abstract

Source: Clinical Journal of Oncology Nursing - November 21, 2018 Category: Nursing Authors: Brutcher E, Christensen D, Hennessey Smith M, Koutlas JB, Sellers JB, Timmons T, Thompson J Tags: Clin J Oncol Nurs Source Type: research