The histologic diagnosis of IgG4 ‐related disease on small biopsies: Challenges and pitfalls

ConclusionPatients with a presumptive diagnosis of IgG4 ‐RD but lacking characteristic pathologic features of this disease appear clinically similar to those that meet current pathologic guidelines. An elevated IgG4:total IgG is the most sensitive pathologic feature and ISH provides a robust quantitation platform. We recommend evaluating tumefactive ly mphoplasmacytic infiltrates with increased IgG4:IgG, regardless of histological features, for IgG4‐RD.This article is protected by copyright. All rights reserved.

Source: Histopathology - November 8, 2018 Category: Pathology Authors: Kshitij Arora, Miguel Rivera, David T. Ting, Vikram Deshpande Tags: Original Article Source Type: research