Interleukin-17 Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling

The role of TCR in establishing IL-17 producing γδ T (Tγδ17) cell lineage identity during thymic development remains controversial. Spidale et al. identify a Sox13hi progenitor to Vγ2+ Tγδ17 cells and demonstrate that progenitor programming is dependent on SOX13 and TCF7 but independent of γδTCR.

Source: Immunity - November 6, 2018 Category: Allergy & Immunology Authors: Nicholas A. Spidale, Katelyn Sylvia, Kavitha Narayan, Bing Miu, Michela Frascoli, Heather J. Melichar, Wu Zhihao, Jan Kisielow, Amy Palin, Thomas Serwold, Paul Love, Michihiro Kobayashi, Momoko Yoshimoto, Nitya Jain, Joonsoo Kang Tags: Article Source Type: research