The absence of Caspase 1/11 leads to fat tissue modulation and a anti-tumor activity of Brown adipose tissue against breast cancer cells

Background: Fat tissues can regulate cancer development by modulating inflammatory response. However, the role of NLRP3 inflammasome in white and brown adipose tissues in this context is poorly understood. Here, we aimed to characterize the role of caspase 1/11 and NLRP3 inflammasome components in the lipidomic profile of brown and white adipocytes and their function in breast cancer cells activation. Brown and white adipose tissue were isolated from wild type, caspase-1/11 and NLRP3 knockout mice.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research