Managing common infections: guidance for primary care

This guidance for managing common infections, including upper and lower respiratory, and urinary tract infections was updated in October 2018.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Urinary tract infections (UTIs) are one of the most frequent diseases encountered by humans worldwide. The presence of multidrug-resistant (MDR) uropathogenic Escherichia coli (UPEC) harboring several virulence f...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
In this study, we aimed to analyze the effect of hydrogen peroxide on the production of this biofilm component. To achieve this goal, 25 clinical E. coli strains isolated from patients with urinary tract infections were used. These bacterial strains were characterized based on their growth characteristics, their ability to form biofilm and their capacity to produce cellulose upon exposure to sub-lethal concentrations of hydrogen peroxide growth, and the biofilm formation of these strains was analyzed. Our results revealed that the analyzed uropathogenic E. coli strains slightly, but significantly, reduced growth and biofil...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ConclusionsThe rates of resistance to FQ were high. The mutations of DNA gyrase, topoisomerase IV and the prevalence of PMQR genes in E. coli and K. pneumonia isolates were alarming. Moreover, the combination of these resistance mechanisms plays an important role in high-level resistance to FQ.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Klotho is one of a number of well-known longevity-associated genes. The amount of klotho observed in tissues declines steadily with advancing age. Interventions that increase levels of klotho have been shown to slow measures of aging to some degree in animal studies. Beyond life span, klotho is also strongly associated with cognitive function. More klotho is better in this case as well. Artificially raised levels of klotho might one day be used as a form of enhancement therapy, capable of improving cognitive function even in younger people. In the research noted here, scientists uncover one of the mechanisms linking...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Acinetobacter baumannii is an important Gram negative opportunistic nosocomial bacterial, which is listed as one of the six most important multidrug resistant (MDR) pathogens in hospitals worldwide by the Infectious Diseases Society of America in 2006 [1,2]. 2017, A. baumannii is also classified in the highest level of “critical” by WHO because it is resistant to a great deal of antibiotics, including carbapenems [3]. A. baumannii can cause a broad range of severe infections, including ventilator associated pneumonia (VAP), bloodstream infections, skin and soft tissue infections, urinary tract infections, woun ...
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research
Public Health England has published reference materials for primary care on diagnosing and understanding culture results for urinary tract infections (UTI).
Source: NHS Networks - Category: UK Health Source Type: news
People with diabetes mellitus are at higher risk of developing serious ascending infections of the urinary tract. The traditional explanation has focused on the role of glycosuria in promoting bacterial growth. Using mouse models, Murtha et al. demonstrate that when the intracellular insulin signaling pathway is compromised, antimicrobial defenses are compromised too, and the mice are unable to effectively handle uropathogenic E. coli introduced experimentally into the urinary tract. These observations strongly support the hypothesis that the antimicrobial defenses of the kidney are dependent on insulin, and the urinary tr...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
We report that type 2 diabetic mice have increased UTI risk. Moreover, insulin-resistant prediabetic mice have increased UTI susceptibility, independent of hyperglycemia or glucosuria. To identify how insulin resistance affects renal antimicrobial defenses, we genetically deleted the insulin receptor in the kidney’s collecting tubules and intercalated cells. Intercalated cells, located within collecting tubules, contribute to epithelial defenses by acidifying the urine and secreting antimicrobial peptides (AMPs) into the urinary stream. Collecting duct and intercalated cell–specific insulin receptor deletion di...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
ConclusionsSufficient nurse staffing and higher professional titles of nurses might contribute to reducing the incidence of major immobility complications. Nurse experience was not related to the incidence of major immobility complications. However, the association between nurse education level and the incidence of major immobility complications requires further investigation.This article is protected by copyright. All rights reserved.
Source: Journal of Nursing Management - Category: Nursing Authors: Tags: Original Article Source Type: research
MONDAY, Nov. 12, 2018 -- If your urinary tract infection isn't responding to antibiotics, you could be headed for a fast relapse, researchers say. In a new study of 151 adults with antibiotic-resistant UTIs, investigators found that these patients...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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