Expanded larotrectinib data confirm findings on efficacy and safety in adult and pediatric patients with TRK fusion cancer across various tumor types (for specialized target groups only)

Data presented across 122 adult and pediatric patients (55 patients from primary dataset plus supplementary dataset with 67 additional patients) with TRK fusion cancer across various tumor types / Integrated dataset on larotrectinib demonstrated high overall response rate of 81 percent (63 percent partial responses and 17 percent complete responses), per investigator assessment / For the initial 55 patients, ongoing responses at 12 months improved to 75 percent with longer follow-up; ongoing responses in the supplementary dataset were 81 percent at 12 months; median duration of response not reached at a respective follow-up of 17.6 and 7.4 months / 84 percent of responding patients in the integrated dataset remained on treatment or underwent surgery for curative intent / Larotrectinib showed favorable safety profile with majority of adverse events grade 1 or 2 / Larotrectinib is currently under regulatory review in the EU and U.S.
Source: Bayer Company News - Category: Pharmaceuticals Source Type: news