Symmetrical (SDMA) and asymmetrical dimethylarginine (ADMA) in sepsis: high plasma levels as combined risk markers for sepsis survival

The aim of this study was to determine whether plasma concentrations of SDMA and ADMA are markers for sepsis survival. Increased plasma concentrations of SDMA and ADMA are associated with sepsis severity. The findings suggest reduced NO bioavailability in non-survivors of sepsis. The authors state that one may use individual SDMA and ADMA levels to identify patients at risk. In view of the pathophysiological role of NO they conclude that the vascular system and immune response are most severely affected when SDMA and ADMA levels are high.

Source: Current Awareness Service for Health (CASH) - October 19, 2018 Category: Consumer Health News Source Type: news