Antibiotics has more impact on mortality than other early goal-directed therapy components in patients with sepsis: An instrumental variable analysis

This study estimates the effect of each of the EGDT components, as well as of the antibiotics, on length-of-stay and mortality. Among patients entering ER with infection and shock or hypoperfusion criteria, the use of appropriate antibiotics in the first 3 h is the measure that has the greatest impact on survival. In addition, among patients with hyperlactatemia>4 mmol/L, the clearance of>10% of lactate during resuscitation is associated with better outcomes.

Source: Current Awareness Service for Health (CASH) - October 19, 2018 Category: Consumer Health News Source Type: news