Optimization of an empiric vancomycin dosing algorithm for improved target concentration attainment in patients with thermal injury

Thermal injury invokes a hypermetabolic response in patients that affects many physiological processes, including drug metabolism [1,2]. Many studies have demonstrated the augmented dosing recommendations of several medications in patients with thermal injury, secondary to increased clearances (CL) and variable volumes of distribution (Vd) [3 –8]. Vancomycin pharmacokinetics have been demonstrated significantly different in patients with thermal versus non-thermal injuries and even that of others critically injured [9–12].

Source: Burns : Journal of the International Society for Burn Injuries - October 16, 2018 Category: Cosmetic Surgery Authors: David M. Hill, Sai R. Velamuri, Julio Lanfranco, Ivan Romero Legro, Scott E. Sinclair, William L. Hickerson Source Type: research