Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism [Medical Sciences]
Tumor hypoxia reduces the effectiveness of radiation therapy by limiting the biologically effective dose. An acute increase in tumor oxygenation before radiation treatment should therefore significantly improve the tumor cell kill after radiation. Efforts to increase oxygen delivery to the tumor have not shown positive clinical results. Here we show...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Martin Benej, Xiangqian Hong, Sandip Vibhute, Sabina Scott, Jinghai Wu, Edward Graves, Quynh-Thu Le, Albert C. Koong, Amato J. Giaccia, Bing Yu, Shih-Ching Chen, Ioanna Papandreou, Nicholas C. Denko Tags: Biological Sciences Source Type: research
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