Copper-Catalyzed Radical Cross-Coupling of Redox-Active Oxime Esters, Styrenes and Boronic Acids.

Copper-Catalyzed Radical Cross-Coupling of Redox-Active Oxime Esters, Styrenes and Boronic Acids.
Angew Chem Int Ed Engl. 2018 Oct 08;:
Authors: Xiao WJ, Yu XY, Zhao QQ, Chen J, Chen JR
Abstract
A visible light-driven, copper-catalyzed three-component radical cross-coupling of oxime esters, styrenes, and boronic acids have been developed. Key steps of this protocol involve catalytic generation of iminyl radical from redox-active oxime ester and subsequent C-C bond cleavage to cyanoalkyl radical. Upon its addition to styrene, the newly formed benzylic radical undergoes coupling with boronic acid-derived ArCu(II) complex to achieve 1,1-diarylmethane-containing alkylnitriles.
PMID: 30295976 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - October 8, 2018 Category: Chemistry Authors: Xiao WJ, Yu XY, Zhao QQ, Chen J, Chen JR Tags: Angew Chem Int Ed Engl Source Type: research