Pd-Catalyzed Intermolecular Arylcarbonylation of Unactivated Alkenes: Incorporation of Bulky Aryls at Room Temperature.

Pd-Catalyzed Intermolecular Arylcarbonylation of Unactivated Alkenes: Incorporation of Bulky Aryls at Room Temperature.
Angew Chem Int Ed Engl. 2018 Oct 08;:
Authors: Liu G, Li X, Chen P
Abstract
A Pd-catalyzed intermolecular arylcarbonylation of unactivated alkenes has been established herein. Unsymmetric diaryliodonium salts (DAIS) are used as arylation reagents, in which the bulky aryls (ArL) are exclusively incorporated into the arylcarbonylated products bearing the ArL group and a carboxylic ester group at the α- and β-carbon position on the terminal C-C double bond, respectively. The reaction features excellent chemo- and regio-selectivities and high functional group tolerance under very mild reaction conditions.
PMID: 30295983 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - October 8, 2018 Category: Chemistry Authors: Liu G, Li X, Chen P Tags: Angew Chem Int Ed Engl Source Type: research