MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population
ConclusionsDecrease in the rates of perioperative outcomes parallels improvements in patient selection and perioperative management of early-stage NSCLC resection patients. Predictors of pulmonary complication could be used to improve selection criteria for surgery and to reduce the incidence of pulmonary complication in these patients.
In this study, we reported the safety and efficacy of hypofractionated 192Ir source stereotactic ablative brachytherapy (SABT) with coplanar template assistance for peripheral lung cancer, and compared the dosimetric parameters between SABT and stereotactic body radiotherapy (SBRT). Material and methods: Thirty-three peripheral lung cancer patients, with the gross lung tumor volume (GTVL) 0.05); the remaining dosimetric parameters were significantly lower in SABT than in SBRT (all p
Streptomyces-derived natural products have been become a major focus of anti-tumor drug discovery studies. Neoantimycin F (NAT-F), was isolated from Streptomyces conglobatus by our group. Here, we examined the anti-cancer activities and its underlying molecular mechanisms implicated in NAT-F–induced apoptosis of non–small cell lung cancer (NSCLC) cells. Our results showed that NAT-F exerted excellent growth-inhibitory activity against PC9 and H1299 cells in a concentration-dependent manner. NAT-F–induced cell cycle arrest at S and G0/G1 phase in PC9 and H1299 cells, respectively. Further investigation rev...
British Journal of Cancer, Published online: 18 September 2019; doi:10.1038/s41416-019-0574-7The lytic activity of VSV-GP treatment dominates the therapeutic effects in a syngeneic model of lung cancer
ConclusionsAlcohol consumption was minimally associated with all-cancer risk. Cigarette smoking clearly increased all-cancer risk, with females being more affected than males. Combined use of alcohol and tobacco increased the risk of developing all, colon, and prostate cancers. A “U-shaped” multiplicative interaction was observed for breast cancer when alcohol and tobacco were used in combination.
Canon Medical Systems said the majority of its CT scanners and software have...Read more on AuntMinnie.comRelated Reading: Canon installs 3T MRI scanner in Colo. Canon makes 1st Alphenix Core+ install in Fla. Canon launches Encore Orian MR upgrade program Canon delivers 1st Alphenix 4D CT to W.Va. hospital Canon gets FDA nod for AI-powered CT reconstruction
Adding radiation after progression on immunotherapy increased progression-free survival in some patients.Medscape Medical News
Differential contribution of protein phosphatase 1α to cell transformation of different cell types. Oncol Rep. 2019 Aug 08;: Authors: Chen JM, Chen KC, Chiu SC, Chen RY, Hsia JY, Huang YJ, Yu CR Abstract Protein phosphorylation plays roles in cell transformation. Numerous protein kinase enzymes actively participate in the formation of various types of cancer by phosphorylating downstream substrates. Aurora‑A is a widely known Serine/Threonine (Ser/Thr) oncogenic kinase, which is upregulated in more than twenty types of human cancer. This enzyme phosphorylates a wide range of substrates. For exa...
Conditions: Patient Outcome Assessment; Morbidity; Mortality Intervention: Procedure: Pulmonary parenchyma resection, lobectomy, pneumonectomy, sleeve lobectomy, extended lobectomy/pneumonectomy Sponsor: AHEPA University Hospital Completed
Conditions: Recurrent Lung Non-Small Cell Carcinoma; Stage III Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Unresectable Lung Non-Small Cell Carcinoma Interventions: Drug: Carboplatin; Drug: Cisplatin; Biological: Durvalumab; Drug: Etoposide; Drug: Paclitaxel; Drug: Pemetrexed; Drug: Pemetre...