Solid-Phase Conversion of Four Stereoisomers into a Single Enantiomer.

Solid-Phase Conversion of Four Stereoisomers into a Single Enantiomer.
Angew Chem Int Ed Engl. 2018 Oct 02;:
Authors: Engwerda T, Mertens H, Tinnemans P, Meekes H, Rutjes FPJT, Vlieg E
Abstract
Viedma ripening is an emerging method for the solid phase deracemization of mixtures of enantiomers. Up to now, the scope of the method has remained limited to molecules with a single stereocenter. We show here that the method can be extended to obtain a single enantiomer from a mixture of stereoisomers with two different stereocenters. In addition, we show that using tailor-made chiral additives, the conversion time can be reduced by a factor of 100.
PMID: 30277304 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - October 2, 2018 Category: Chemistry Authors: Engwerda T, Mertens H, Tinnemans P, Meekes H, Rutjes FPJT, Vlieg E Tags: Angew Chem Int Ed Engl Source Type: research