Molecular and cellular characterizations of human cherubism: disease aggressiveness depends on osteoclast differentiation

Cherubism is a rare autosomal dominant disorder of the jaws caused by mutation of the SH3BP2 gene. The bone is replaced by a fibrous granuloma containing multinucleated giant cells. Cells of the cherubism granulo...

Source: Orphanet Journal of Rare Diseases - September 20, 2018 Category: Internal Medicine Authors: Natacha Kadlub, Quentin Sessiecq, Marion Mandavit, Aurore Coulomb L ’Hermine, Cecile Badoual, Louise Galmiche, Ariane Berdal, Vianney Descroix, Arnaud Picard and Amélie E. Coudert Tags: Research Source Type: research