The Human Cell Atlas Bone Marrow Single-Cell Interactive Web Portal

The advent of new innovative technologies for single-cell genomics provides nearly limitless opportunities for exploring tissue cellular variation at single-molecule resolution. Single-cell RNA profiling has already revealed hidden heterogeneity within presumed homogenous populations, novel intermediates and developmental trajectories [1-5]. Although thousands of cells can be readily captured and profiled with these technologies, the cellular composition of in vivo cellular niches are complex, currently requiring selective strategies for isolation, such as flow cytometry sorting and a priori defined surface markers to capture and profile sufficient depths of rare cell populations [3, 5-8].

Source: Experimental Hematology - September 20, 2018 Category: Hematology Authors: Stuart Hay, Kyle Ferchen, Kashish Chetal, H. Leighton Grimes, Nathan Salomonis Source Type: research