Triaging treatable traits in asthma

Respirology, EarlyView.
Source: Respirology - Category: Respiratory Medicine Authors: Source Type: research

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This study describes the long-term comorbidity profile and treatment burden among people with HIV-1 infection.Methods: This retrospective study included Medicaid claims data from patients with ≥1 antiretroviral (ARV) claim between 2016 and 2017 (most recent claim defined the index date), ≥1 HIV diagnosis within 1 year before index, age ≥18 years at first HIV diagnosis and
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Authors: Kalmarzi RN, Ahmadi S, Rahehagh R, Fathallahpour A, Khalafi B, Kashefi H, Roshani D, Zaryan RN, Mohamadi S, Kooti W Abstract BACKGROUND: The extensive impacts of vitamin D on the immune system has gathered the attention of scholars in last years. In this regard, studies about vitamin D and incidence of asthma have showed various results. The aim of this study was to evaluate the effect of vitamin D supplements on clinical outcomes in asthmatic children with vitamin D insufficiency. MATERIALS &METHODS: This before-after interventional study was conducted on all asthmatic children who attended the Be...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
This study investigated the protective effects of ascorbic acid in combination with calcitriol on airway remodelling in ovalbumin (OVA)-induced chronic asthma.Materials and methods: BALB/c mice were assigned into seven groups: (1) Control; (2) Asthma; (3) Ineffective C (orally 39 mg/kg ascorbic acid); (4) Ineffective D (intraperitoneally 1.5 μg/kg calcitriol); (5) Effective C (orally 130 mg/kg ascorbic acid); (6) Effective D (intraperitoneally 5 μg/kg calcitriol); (7) Combination (orally 39 mg/kg ascorbic acid + intraperitoneally 1.5 μg/kg calcitriol). All an...
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Publication date: Available online 16 January 2020Source: Journal of Molecular Graphics and ModellingAuthor(s): Yonghui Lv, Yu Wang, Xin Zheng, Guizhao LiangAbstractVEGFR2, vascular endothelial growth factor receptor 2, plays an important role in anti-angiogenesis and is an effective target for inhibiting tumor cell proliferation and metastasis. Many small molecule inhibitors have so far exhibited fine therapeutic effects but do not rule out some adverse reactions. From the perspective of the new use of old drugs, we use a combination of two different docking methods, molecular dynamics simulations and quantum-chemical cal...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
Publication date: Available online 17 January 2020Source: Revista Clínica Española (English Edition)Author(s): E. Martínez-Moragón, J. Delgado, S. Mogrovejo, T. Fernández-Sánchez, On behalf of the grupo de investigación STEP, Jesús Jiménez López, Miguel Ángel Moscardó Orenes, Patricia Prieto Montaño, Miguel Torrecillas Toro, Begoña Cueva Oliver, Ángel Ferrer Torres, Purificación González Delgado, Teodorikez Wilfox Jiménez Rodríguez, Brian Vila Auli, Juan José Zapata Yebenes, Marí...
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
BPA exposure may activate an immune system response linked to asthma that is passed down through generations, according to a study published in the journal ofProteome Research.Science Daily
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
The Pharmacogenomics Journal, Published online: 17 January 2020; doi:10.1038/s41397-019-0140-yPharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation
Source: The Pharmacogenomics Journal - Category: Drugs & Pharmacology Authors: Source Type: research
In this report, we compared [1] pathways identified from network analysis using genes derived from published genome-wide family-based and association studies for otitis media, sinusitis, and lung phenotypes, to [2] pathways identified using differentially expressed genes from RNA-sequence data from lower airway, sinus, and middle ear tissues, in particular cholesteatoma tissue compared to middle ear mucosa. For otitis media, a large number of genes (n = 1,806) were identified as differentially expressed between cholesteatoma and middle ear mucosa, which in turn led to the identification of 68 pathways that are enriched in ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Authors: Eusebio M, Kraszula L, Kupczyk M, Kuna P, Pietruczuk M Abstract Preliminary studies demonstrated the potential role of CD8+CD25+ T regulatory cells (Tregs) in asthma. However, published data with regard to the relevance of signaling pathways that govern Tregs homeostasis are limited and conflicting. The first aim of this study was to characterize the phosphorylation of STAT-5 in CD8+CD25+ Tregs. The second aim was to investigate the ability of CD8+CD25+ Tregs from patients and controls to respond to interleukin (IL)-2 treatment in vitro. Twenty-five healthy subjects (NC) and 50 patients with either severe ...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Publication date: Available online 15 January 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Rory Chan, Chris RuiWen Kuo, Brian Lipworth
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
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