Methotrexate Effective in Subcutaneous Psoriasis

(MedPage Today) -- Over 40% of patients achieved PASI 75 response in 16-week trial
Source: MedPage Today Dermatology - Category: Dermatology Source Type: news

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Conditions:   Mesenchymal Stromal Cells;   Psoriasis;   Drug Effect;   Drug Toxicity Intervention:   Biological: Umbilical cord mesenchymal stem cells Sponsors:   Guangdong Provincial Hospital of Traditional Chinese Medicine;   Peking Union Medical College Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
ConclusionsThe elevated burden of HZ in Japanese individuals harboring IC conditions and chronic disorders documented in our study underlines the need for prevention of HZ in people with these conditions.FundingGlaxoSmithKline Biologicals SA.
Source: Dermatology and Therapy - Category: Dermatology Source Type: research
ConclusionsPsoriasis was independently associated with risk of depression. These results may help clinicians identify particularly high ‐risk individuals.
Source: British Journal of Dermatology - Category: Dermatology Authors: Tags: Epidemiology Source Type: research
People with psoriasis may be at increased risk of sexual dysfunction, particularly when they also suffer from mood disorders or arthritis, a research review suggests.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Dermatology News Source Type: news
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Ciechanowicz P, Rakowska A, Sikora M, Rudnicka L Abstract The Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway is a ubiquitous intracellular signaling network. Selective JAK-inhibitors have anti-inflammatory properties and have been approved in many countries for the treatment of rheumatoid arthritis (tofacitinib, baricitinib) and myelofibrosis or polycythemia vera (ruxolitinib). The aim of the publication was to summarize and critically analyze the efficacy and safety of JAK-inhibitors in skin diseases, such as psoriasis, alopecia areata, atopic dermatitis and vitilig...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
CONCLUSION: The aim of this review, other than providing a summarized update on the clinical knowledge on this special topic, is also to raise awareness for the need to conduct larger systematic studies in order to adequately evaluate the use of biologics in these special patient categories and therefore draw definite conclusions on their safety profile. PMID: 30428753 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Authors: Diotallevi F, Campanati A, Radi G, Molinelli E, Offidani A Abstract BACKGROUND: Data concerning clinical experience in real world setting with ixekizumab for psoriasis are still exiguous and aim of this report is to provide our experience in the use of ixekizumab in out-patient setting. METHODS: Fifteen Caucasian individuals (10 male, 5 females; mean age 58.1; range 30-75 years) affected by moderate to severe plaque psoriasis (PASI≥10 e/o DLQI≥10 e/O BSA≥10) were treated with Ixekizumab, following dosing regimen of technical data sheet and clinically evaluated both after 4 weeks (T4) and 12 we...
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Publication date: Available online 15 November 2018Source: International Journal of PharmaceuticsAuthor(s): Prerana Carter, Balaji Narasimhan, Qun WangAbstractTransdermal drug delivery (TDDS) has been highly explored in the past couple of decades due to benefits such as increased patient compliance, improved drug release, tissue targeting, avoiding the presystemic metabolism in the liver etc. However, the stratum corneum poses as the rate limiting barrier to the permeation of drugs through the skin, which has been a continuous challenge in TDDS. This review covers the various types of nanoparticles and nanoemulsions that a...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
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