Non-canonical NF- κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy

It is known that the NF- κB pathway plays a crucial role in supporting tumor initiation, progression, and the radioresistance of tumor cells. Hou et al. demonstrate that the deficiency of non-canonical NF-κB, but not canonical NF-κB, promotes radiation-induced anti-tumor immunity by regulating the STING-mediated type I IFN expression.

Source: Immunity - August 28, 2018 Category: Allergy & Immunology Authors: Yuzhu Hou, Hua Liang, Enyu Rao, Wenxin Zheng, Xiaona Huang, Liufu Deng, Yuan Zhang, Xinshuang Yu, Meng Xu, Helena Mauceri, Ainhoa Arina, Ralph R. Weichselbaum, Yang-Xin Fu Tags: Article Source Type: research