Targeting Phosphodiesterase-5 by Vardenafil Improves Vascular Graft Function

Ischaemia reperfusion (IR) injury occurs during vascular graft harvesting and implantation during vascular/cardiac surgery. Elevated intracellular cyclic guanosine monophosphate (cGMP) levels contribute to an effective endothelial protection in different pathophysiological conditions. The hypothesis that the phosphodiesterase-5 inhibitor vardenafil would protect vascular grafts against IR injury by upregulating the nitric oxide –cGMP pathway in the vessel wall of the bypass graft was investigated.

Source: Journal of Vascular Surgery - August 22, 2018 Category: Surgery Authors: G. Veres, M. Hagenhoff, H. Schmidt, T. Radovits, S. Loganathan, Y. Bai, S. Korkmaz-Ic öz, P. Brlecic, A.A. Sayour, M. Karck, G. Szabó Tags: Selected Abstract from the August Issue of the European Journal of Vascular and Endovascular Surgery Source Type: research