Response:

We read with great interest the letter by Spinzi et  al1 commenting on our article2 and warning about simethicone and its potential harmful effect when it is used for GI endoscopy. We agree with their concerns based on reports of crystallization in the endoscope channels when simethicone is used in the water pump.3 The concentration of simethicone u sed varies and is not standardized, but frequently 10 to 20 mL (1-2 g) are poured into 1 liter of water. Then the water is flushed; applied on the mucosa covered with bubbles, mucus, or both; and directly suctioned.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research