Marked alterations in the structure, dynamics and maturation of growth plate likely explain growth retardation and bone deformities of young Hyp mice

Mechanisms underlying growth impairment and bone deformities in X-linked hypophosphatemia are not fully understood. We here describe marked alterations in the structure, dynamics and maturation of growth plate in growth-retarded young Hyp mice, in comparison with wild type mice. Hyp mice exhibited reduced proliferation and apoptosis rates of chondrocytes as well as severe disturbance in the process of chondrocyte hypertrophy disclosed by abnormal expression of proteins likely involved in cell enlargement, irregular chondro-osseous junction and disordered bone trabecular pattern and vascular invasion in the primary spongiosa.

Source: Bone - August 7, 2018 Category: Orthopaedics Authors: Roc ío Fuente, Helena Gil-Peña, Débora Claramunt-Taberner, Olaya Hernández-Frías, Ángela Fernández-Iglesias, Francisco Hermida-Prado, Gonzalo Anes-González, Isabel Rubio-Aliaga, Jose Manuel Lopez, Fernando Santos Tags: Full Length Article Source Type: research