LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis

Treg cells control of tissue resident macrophages and ILC3 function has not been elucidated. Bauche et  al. demonstrate that LAG-3+ Treg cells suppress the production of pro-inflammatory cytokines by CX3CR1+ macrophages and thereby inhibit ILC3-driven colitis.

Source: Immunity - August 7, 2018 Category: Allergy & Immunology Authors: David Bauch é, Barbara Joyce-Shaikh, Renu Jain, Jeff Grein, Karin S. Ku, Wendy M. Blumenschein, Stephanie C. Ganal-Vonarburg, Douglas C. Wilson, Terrill K. McClanahan, Rene de Waal Malefyt, Andrew J. Macpherson, Lakshmanan Annamalai, Jennifer H. Yearley, Tags: Article Source Type: research