PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells

Th1 cells are known for their enhanced stability, so mechanisms that mediate their flexibility are poorly studied. Here, Stathopoulou et  al. demonstrate that plasticity of Th1 cells to Tbet+iTreg cells is mediated by PD-1 signaling via asparaginyl endopeptidase (AEP). AEP inhibition enhanced iTreg cells in GvHD and tumor models.

Source: Immunity - July 24, 2018 Category: Allergy & Immunology Authors: Chaido Stathopoulou, Arunakumar Gangaplara, Grace Mallett, Francis A. Flomerfelt, Lukasz P. Liniany, David Knight, Leigh A. Samsel, Rolando Berlinguer-Palmini, Joshua J. Yim, Tania C. Felizardo, Michael A. Eckhaus, Laura Edgington-Mitchell, Jonathan Marti Tags: Article Source Type: research