Metal-Free Direct C-H Cyanation of Alkenes.

Metal-Free Direct C-H Cyanation of Alkenes.
Angew Chem Int Ed Engl. 2018 Jul 11;:
Authors: Wang X, Studer A
Abstract
A metal-free direct alkene C-H cyanation is described. Directing groups are not required and the mechanism involves electrophilic activation of the alkene by a cyano iodine(III) species generated in situ from a [bis(trifluoroacetoxy)iodo]arene and trimethylsilyl cyanide as the cyanide source. This C-H functionalization can be conducted at gram-scale and for non-cyclic 1,1- and 1,2-disubstuted alkenes high stereoselectivity is achieved, rendering the method highly valuable.
PMID: 29995341 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - July 11, 2018 Category: Chemistry Authors: Wang X, Studer A Tags: Angew Chem Int Ed Engl Source Type: research