Boy, 5, remembered in tear-jerking hilarious obituary he wrote for himself

Garrett Michael Matthias, of Iowa, was diagnosed with a rare form of cancer,  Stage 4 Alveolar Fusion Negative Rhabdomyosarcoma (ARMS), in September last year. He died on June 6.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Publication date: September 2018Source: Human Pathology: Case Reports, Volume 13Author(s): Kimihde Kusafuka, Takuya Kawasaki, Tetsuro Onitsuka, Tomohito Fuke, Takuro Nakamura, Hiroshi Minato, Masato Nagaoka, Takashi Kitani, Tomoyuki Kamijo, Yoshiyuki Iida, Takashi Nakajima, Takashi SuginoAbstractSclerosing/spindle cell rhabdomyosarcoma (SRMS) is a rare type of rhabdomyosarcoma. We immunohistochemically and genetically examined a case of SRMS of the oral floor. The patient was a 19-year-old female, who noticed swelling in the right oral floor. Under a diagnosis of a sublingual tumor, tumor resection was performed. The tumor...
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
Publication date: June 2018Source: Seminars in Cancer Biology, Volume 50Author(s): Marco Wachtel, Beat W. SchäferAbstractDriver oncogenes are prime targets for therapy in tumors many of which, including leukemias and sarcomas, express recurrent fusion transcription factors. One specific example for such a cancer type is alveolar rhabdomyosarcoma, which is associated in the majority of cases with the fusion protein PAX3-FOXO1. Since fusion transcription factors are challenging targets for development of small molecule inhibitors, indirect inhibitory strategies for this type of oncogenes represent a more promising appro...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: 3 July 2018Source: Cell Reports, Volume 24, Issue 1Author(s): Lin Xu, Yanbin Zheng, Jing Liu, Dinesh Rakheja, Sydney Singleterry, Theodore W. Laetsch, Jack F. Shern, Javed Khan, Timothy J. Triche, Douglas S. Hawkins, James F. Amatruda, Stephen X. SkapekSummaryIdentifying oncogenic drivers and tumor suppressors remains a challenge in many forms of cancer, including rhabdomyosarcoma. Anticipating gene expression alterations resulting from DNA copy-number variants to be particularly important, we developed a computational and experimental strategy incorporating a Bayesian algorithm and CRISPR/Cas9 “min...
Source: Cell Reports - Category: Cytology Source Type: research
Abstract AIM: To compare therapeutic responses of a vascular-disrupting-agent, combretastatin-A4-phosphate (CA4P), among hepatocellular carcinomas (HCCs) and implanted rhabdomyosarcoma (R1) in the same rats by magnetic-resonance-imaging (MRI), microangiography and histopathology. METHODS: Thirty-six HCCs were created by diethylnitrosamine gavage in 14 rats that were also intrahepatically implanted with one R1 per rat as monitored by T2-/T1-weighted images (T2WI/T1WI) on a 3.0T clinical MRI-scanner. Vascular response and tumoral necrosis were detected by dynamic contrast-enhanced (DCE-) and CE-MRI before, 1 h ...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
Publication date: September 2018Source: Human Pathology: Case Reports, Volume 13Author(s): Kimihde Kusafuka, Takuya Kawasaki, Tetsuro Onitsuka, Tomohito Fuke, Takuro Nakamura, Hiroshi Minato, Masato Nagaoka, Takashi Kitani, Tomoyuki Kamijo, Yoshiyuki Iida, Takashi Nakajima, Takashi SuginoAbstractSclerosing/spindle cell rhabdomyosarcoma (SRMS) is a rare type of rhabdomyosarcoma. We immunohistochemically and genetically examined a case of SRMS of the oral floor. The patient was a 19-year-old female, who noticed swelling in the right oral floor. Under a diagnosis of a sublingual tumor, tumor resection was performed. The tumor...
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
Publication date: June 2018Source: Seminars in Cancer Biology, Volume 50Author(s): Marco Wachtel, Beat W. SchäferAbstractDriver oncogenes are prime targets for therapy in tumors many of which, including leukemias and sarcomas, express recurrent fusion transcription factors. One specific example for such a cancer type is alveolar rhabdomyosarcoma, which is associated in the majority of cases with the fusion protein PAX3-FOXO1. Since fusion transcription factors are challenging targets for development of small molecule inhibitors, indirect inhibitory strategies for this type of oncogenes represent a more promising appro...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: August 2018Source: Cancer Genetics, Volumes 224–225Author(s): Benjamin Hilton, Bo Hong, David Scharnhorst, Maria Longhurst, Kathryn O'Brien, Suying Xu
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
Publication date: 3 July 2018Source: Cell Reports, Volume 24, Issue 1Author(s): Lin Xu, Yanbin Zheng, Jing Liu, Dinesh Rakheja, Sydney Singleterry, Theodore W. Laetsch, Jack F. Shern, Javed Khan, Timothy J. Triche, Douglas S. Hawkins, James F. Amatruda, Stephen X. SkapekSummaryIdentifying oncogenic drivers and tumor suppressors remains a challenge in many forms of cancer, including rhabdomyosarcoma. Anticipating gene expression alterations resulting from DNA copy-number variants to be particularly important, we developed a computational and experimental strategy incorporating a Bayesian algorithm and CRISPR/Cas9 “min...
Source: Cell Reports - Category: Cytology Source Type: research
Authors: Du S, Meng L, Song L, Zhang P, Shou X, Liu C, Li F Abstract In vivo imaging system (IVIS) is a novel and rapidly expanding technology that is widely applied in life sciences, including cell tracing. IVIS is able to quantify biological events, including tumor proliferation, through counting the number of photons emitted from a specimen. PLA802-enhanced green fluorescent protein (EGFP), PLA802-monomeric cherry fluorescent protein (mCherry), RH30-EGFP and RH30-mCherry tumor cells were injected into 18 BALB/c female nude mice subcutaneously with 5×106 cells in 100 µl to quantitatively analyze EGFP ...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
The RAS isoforms are frequently mutated in many types of human cancers, including PAX3/PAX7 fusion-negative rhabdomyosarcoma. Pediatric RMS arises from skeletal muscle progenitor cells that have failed to differentiate normally. The role of mutant RAS in this differentiation blockade is incompletely understood. We demonstrate that oncogenic RAS, acting through the RAF–MEK [mitogen-activated protein kinase (MAPK) kinase]–ERK (extracellular signal–regulated kinase) MAPK effector pathway, inhibits myogenic differentiation in rhabdomyosarcoma by repressing the expression of the prodifferentiation myogenic tra...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
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