Boy, 5, remembered in tear-jerking hilarious obituary he wrote for himself

Garrett Michael Matthias, of Iowa, was diagnosed with a rare form of cancer,  Stage 4 Alveolar Fusion Negative Rhabdomyosarcoma (ARMS), in September last year. He died on June 6.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Source: Histopathology - Category: Pathology Authors: Tags: Lesson of the month Source Type: research
Pediatric Blood&Cancer, EarlyView.
Source: Pediatric Blood and Cancer - Category: Cancer & Oncology Authors: Source Type: research
(University of Arizona Health Sciences) UA Cancer Center researcher harnesses 'big data' to identify targeted treatments for rhabdomyosarcoma, a rare cancer that mostly strikes children and teenagers.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Barr Rhabdomyosarcoma (RMS) is a family of soft tissue cancers that are related to the skeletal muscle lineage and predominantly occur in children and young adults. A specific chromosomal translocation t(2;13)(q35;q14) that gives rise to the chimeric oncogenic transcription factor PAX3-FOXO1 has been identified as a hallmark of the aggressive alveolar subtype of RMS. PAX3-FOXO1 cooperates with additional molecular changes to promote oncogenic transformation and tumorigenesis in various human and murine models. Its expression is generally restricted to RMS tumor cells, thus providing a very specific target for therapeut...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
This study aimed to investigate the potential of a novel HDAC inhibitor, OBP‑801, as a therapeutic agent for the treatment of RMS. We used 8 RMS cell lines in this study. Protein expression patterns, cell proliferation, cell cycle status, and apoptosis in RMS cells after OBP‑801 treatment in vitro were investigated. We also studied the antitumor activity of OBP‑801 in an in vivo xenograft mouse model. We observed cell cycle arrest at the M‑phase and apoptosis in all RMS cell lines after exposure to pharmacological levels of OBP‑801 for 24 h. Immunofluorescence staining revealed that OBP‑801 may i...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Pediatric Blood&Cancer, EarlyView.
Source: Pediatric Blood and Cancer - Category: Cancer & Oncology Authors: Source Type: research
ConclusionsThis study suggests that the combined exposure to PARPi and IR might display a role in the treatment of RMS tumours compared with single-agent exposure, since stronger cytotoxic effects are induced, and compensatory survival mechanisms are prevented.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Cancer, EarlyView.
Source: Cancer - Category: Cancer & Oncology Authors: Source Type: research
Conclusion: The presence of a trabecular pattern helps to differentiate MCC from other SRBC tumors, and specificity approaches that achieved with immunostaining.
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Original Study Source Type: research
Pediatric Blood&Cancer, EarlyView.
Source: Pediatric Blood and Cancer - Category: Cancer & Oncology Authors: Source Type: research
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