Inflammatory signaling and metabolic regulation by nitro-fatty acids

Publication date: 1 August 2018Source: Nitric Oxide, Volume 78Author(s): Oren Rom, Nicholas K.H. Khoo, Y. Eugene Chen, Luis VillacortaAbstractThe addition of nitrogen dioxide (NO2) to the double bond of unsaturated fatty acids yields an array of electrophilic nitro-fatty acids (NO2-FA) with unique biochemical and signaling properties. During the last decade, NO2-FA have been shown to exert a protective role in various inflammatory and metabolic disorders. NO2-FA exert their biological effects primarily by regulating two central physiological adaptive responses: the canonical inflammatory signaling and metabolic pathways. In this mini-review, we summarize current knowledge on the regulatory role of NO2-FA in the inflammatory and metabolic response via regulation of nuclear factor kappa B (NF-κB) and peroxisome proliferator-activated receptor γ (PPARγ), master regulators of inflammation and metabolism. Moreover, the engagement of novel signaling and metabolic pathways influenced by NO2-FA, beyond NF-κB and PPAR signaling, is discussed herein.Graphical abstract

Source: Nitric Oxide - July 11, 2018 Category: Chemistry Source Type: research