Pediatric Type 1 Diabetes: Patients' and Caregivers' Perceptions of Glycemic Control

ConclusionsPatients and caregivers had accurate knowledge of ideal BG range but were less knowledgeable about the meaning of A1C levels and ideal A1C targets. Nevertheless, whether glycemic control was perceived as an A1C measurement or a BG range, A1C levels trended lower for patients when both they and their caregivers had accurate perceptions of glycemic control.RésuméObjectifs1) Décrire la perception des enfants et des adolescents atteints du DT1 et de leurs soignants sur les mesures liées à la régulation glycémique (les concentrations de l'hémoglobine [A1c] et de la glycémie [G]) ; 2) Déterminer la relation entre la perception des patients et des soignants sur les mesures liées à la régulation glycémique par rapport aux concentrations actuelles de l'A1c et à l'observance aux autosoins diabétiques.MéthodesLes patients (de 8 à 18 ans) atteints du DT1 et les soignants ont rempli les questionnaires qui visaient à connaître leur perception sur : 1) ce qu'évalue la concentration de l'A1c ; 2) la valeur cible idéalede l'A1c ; 3) la fourchette de G idéale. Les concentrations hors laboratoire de l'A1c de chacun des patients ont été mesurées. Ils ont également rempli la version révisée de l'Inventaire des capacités &agra...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research

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AbstractBackgroundThe aim of the study is to identify the effect of salt intake and diabetes itself on blood pressure (BP) profile and microalbuminuria in children with type one diabetes mellitus (T1DM). Our hypothesis is that higher amount of salt consumption and/or hyperglycemia may impair blood pressure pattern in children with T1DM.MethodsThis cross-sectional study included 84 children and adolescents with T1DM (62% females, age 13.9  ± 3.2 years, disease duration 7.3 ± 3.1 years, 43% poorly controlled diabetes) and 54 aged- and sex-matched healthy children with an ad...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Authors: Xie Z, Chang C, Huang G, Zhou Z Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by the interaction between genetic alterations and environmental factors. More than 60 susceptible genes or loci of T1D have been identified. Among them, HLA regions are reported to contribute about 50% of genetic susceptibility in Caucasians. There are many environmental factors involved in the pathogenesis of T1D. Environmental factors may change the expression of genes through epigenetic mechanisms, thus inducing individuals with susceptible genes to develop T1D; however, the underlying mechanisms remain ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Source: Archives of Physiology and Biochemistry - Category: Physiology Authors: Source Type: research
AbstractDiabetic ketoacidosis (DKA) is the end result of insulin deficiency in type 1 diabetes mellitus (T1D). Loss of insulin production leads to profound catabolism with increased gluconeogenesis, glycogenolysis, lipolysis, and muscle proteolysis causing hyperglycemia and osmotic diuresis. High levels of counter-regulatory hormones lead to enhanced ketogenesis and the release of ‘ketone bodies’ into the circulation, which dissociate to release hydrogen ions and cause an overwhelming acidosis. Dehydration, hyperglycemia, and ketoacidosis are the hallmarks of this condition. Treatment is effective repletion of ...
Source: Pediatric Drugs - Category: Pediatrics Source Type: research
Purpose: To analyze the evolution of macular vessel density (VD) over 1 year, during early worsening of diabetic retinopathy, in patients with uncontrolled Type 1 diabetes (T1D). Methods: Retrospective study of 12 eyes of 9 patients with T1D with early worsening of diabetic retinopathy imaged with optical coherence tomography angiography. The following data were collected at the time of pan retinal photocoagulation initiation and after 6 and 12 months: vessel density within three retinal plexuses—superficial vascular plexus, intermediate capillary plexus, and deep capillary plexus; foveal avascular zone area, ac...
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
DiabetesMine delves into the misinformation about type 1 diabetes by actress Halle Berry.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
CONCLUSIONS: The present study suggests that young, uncomplicated patients with type 1 diabetes have a higher estimated peak systolic pulmonary artery pressure. Further studies are needed to define the mechanisms underlying this alteration and its clinical consequences. PMID: 32432766 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Exposure to chronic hyperglycemia because of diabetes mellitus can lead to development and progression of diabetic kidney disease (DKD). We recently reported that reduced superoxide production is associated with mitochondrial dysfunction in the kidneys of mouse models of type 1 DKD. We also demonstrated that humans with DKD have significantly reduced levels of mitochondrion-derived metabolites in their urine. Here we examined renal superoxide production in a type 2 diabetes animal model, the db/db mouse, and the role of a mitochondrial protectant, MTP-131 (also called elamipretide, SS-31, or Bendavia) in restoring renal su...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Metabolism Source Type: research
In this volume of The Journal, Kao et al report a retrospective cohort of youth with type 1 diabetes (T1D) with 11 years of data (from 2002-2012) on incidence trends of diabetic ketoacidosis (DKA) in children and adolescents with T1D in British Columbia, Canada. The authors found that among 2615 incident cases of T1D, 32.4% presented in DKA. Rates of DKA at diagnosis remained stable over 11 years with a range of 24.1 to 37.3 per 100 person-years. Similarly, rates of DKA in youth with diagnosed T1D were stable with a range of 4.9 to 7.7 per 100 person-years.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
To estimate the 11-year incidence trend of diabetic ketoacidosis (DKA) at and after the diagnosis of type 1 diabetes.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Original Article Source Type: research
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